Study results from University of Montreal, Research Center update understanding of congenital hypothyroidism epidemiology
2007 SEP 18 -- Data detailed in "Random variability in congenital hypothyroidism from thyroid dysgenesis over 16 years in Québec" have been presented. According to recent research from Quebec, Canada, "Research on the etiology of congenital hypothyroidism from thyroid dysgenesis (CHTD) (comprising mostly ectopy and agenesis) over the past decade has focused on genetic mechanisms. However, the possibility that environmental factors might be involved has been raised by studies showing a seasonal variability of the incidence of CHTD. The objective of this study was to assess the variability in incidence of CHTD in the province of Québec, Canada. AND The Québec provincial newborn screening database was analyzed from January 1990 to December 2005." "Only cases of permanent congenital hypothyroidism with thyroid ectopy or agenesis on scintigraphy were analyzed. During the study period, 1,303,341 children were screened, and 424 cases of permanent congenital hypothyroidism were diagnosed, giving an overall incidence of 1:3074. Of these, 306 had CHTD (overall incidence 1:4259) from either ectopy (n=231) or agenesis (n=75). Over the 16 yr of the study, this incidence remained stable (p=0.57), and no significant variability in monthly incidence was found (p=0.87). The incidence of CHTD did not vary over the observation period, and its monthly variation was random," wrote J. Deladoëy and colleagues, University of Montreal, Research Center. The researchers concluded: "Therefore, environmental factors do not appear to play a significant role in the etiology of CHTD." Deladoëy and colleagues published their study in the Journal of Clinical Endocrinology & Metabolism (Random variability in congenital hypothyroidism from thyroid dysgenesis over 16 years in Québec. Journal of Clinical Endocrinology & Metabolism, 2007;92(8):3158-61). For additional information, contact J. Deladoëy, University of Montreal, Endocrinology Service and Research Center, Sainte-Justine Hospital, H3T 1C5 Quebec, Canada. Publisher contact information for the Journal of Clinical Endocrinology & Metabolism is: Endocrine Society, 8401 Connecticut Avenue, Suite 900, Chevy Chase, MD 20815-5817, USA. Keywords: Canada, Quebec, Congenital Hypothyroidism Epidemiology, Clinical Endocrinology, Congenital Hypothyroidism, Endocrinology, Epidemiology, Metabolism. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
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