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Reports Outline Stem Cell Research Study Findings from L. Zhao and Colleagues

2012 FEB 7 -- A report, "TGF-ß1 regulates differentiation of bone marrow mesenchymal stem cells," is newly published data in Vitamins and Hormones. According to the authors of recent research published in the journal Vitamins and Hormones, "Mesenchymal stromal/stem cells (MSCs) are a small population of stromal cells present in most adult connective tissues, such as bone marrow, fat tissue, and umbilical cord blood. MSCs are maintained in a relative state of quiescence in vivo but, in response to a variety of physiological and pathological stimuli, are capable of proliferating then differentiating into osteoblasts, chondrocytes, adipocytes, or other mesoderm-type lineages like smooth muscle cells (SMCs) and cardiomyocytes."

"Multiple signaling networks orchestrate MSCs differentiating into functional mesenchymal lineages. Among these, transforming growth factor-ß1 (TGF-ß1) has emerged as a key player. Hence, we summarize the effects of TGF-ß1 on differentiation of MSCs toward different lineages. TGF-ß1 can induce either chondrogenic or SMC differentiation of MSCs in vitro. However, it requires cell-cell and cell-matrix interactions, similar to development of these tissues in vivo. The effect of TGF-ß1-regulated osteogenic differentiation of MSCs in vitro depends on the specific culture conditions involved. TGF-ß1 inhibits adipogenic differentiation of MSCs in monolayer culture," wrote L. Zhao and colleagues.

The researchers concluded: "Using this information, we may optimize the culture conditions to differentiate MSCs into desired lineages."

Zhao and colleagues published their study in Vitamins and Hormones (TGF-ß1 regulates differentiation of bone marrow mesenchymal stem cells. Vitamins and Hormones, 2011;87():127-41).

For additional information, contact L. Zhao, Escape Therapeutics Inc, San Jose, California, United States.

Keywords: City:San Jose, State:California, Country:United States, Region:North and Central America, Bone Research, Immune System, Stem Cell Research.

This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2012, Life Science Weekly via NewsRx.com.