Study results from College of Medicine in the area of colonic disease therapy published
2007 NOV 12 -- Fresh data on colonic disease are presented in the report 'The natural history of perianal Crohn's disease.' According to a study from the United States, "Perianal lesions are exceedingly common in Crohn's disease and many patients have more than one type of lesion. Skin tags, fissures and haemorrhoids may persist over time and are usually managed expectantly or with topical therapy." "Perianal and rectovaginal fistulas and associated abscesses often require both local and systemic therapy, and recurrence is common. In general, the clinical course of Crohn's disease is more aggressive in patients with perianal involvement. Established risk factors for perianal disease include colonic disease and young age at disease onset. Classification schema now recognize perianal fistulas as distinct from other forms of penetrating Crohn's disease. Genetic susceptibility factors for perianal disease may exist, but they remain incompletely delineated at present. There is hope that immunosuppressive and biotechnology medications will influence the natural history of perianal disease by preventing invasive surgeries, disease complications and recurrence, but this needs to be confirmed," wrote S.B. Ingle and colleagues, College of Medicine. The researchers concluded: "Cancer, a rare complication of perianal disease, must be suspected when lesions persist despite therapy." Ingle and colleagues published their study in Digestive and Liver Disease (The natural history of perianal Crohn's disease. Digestive and Liver Disease, 2007;39(10):963-9). For more information, contact S.B. Ingle, Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905 USA.. Publisher contact information for the journal Digestive and Liver Disease is: Pacini Editore, Via Della Gherardesca-Zona Industriale Ospedaletto, 56121 Pisa, Italy. Keywords: United States, Rochester, Colonic Disease Therapy, Colonic Disease, Crohn Disease, Gastroenterology, Gastrointestinal, Liver Disease, Therapy, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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