Crohn Disease


Research on inflammatory bowel disease genetics discussed by scientists at University of Ioannina



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This article was published in Gastroenterology Week, which you can subscribe to online.
2007 NOV 12 -- Data detailed in 'Crohn's disease incidence evolution in North-western Greece is not associated with alteration of NOD2/CARD15 variants' have been presented. In this recent report, researchers in Ioannina, Greece conducted a study "To assess the trends in the incidence of inflammatory bowel disease (IBD) over 23 years in the same area and to identify genetic factors related to incidence evolution Patients with IBD arising from North-western Greece were systematically recorded through the 1983-2005 period. Trends in disease incidence and genetic patterns related to CARD15 variants were documented and correlated A total of 447 patients with IBD were recorded (23.5% Crohn's disease, 72.7% Ulcerative colitis and 3.8% indeterminate colitis)."

"Mean annual incidence rates of CD and UC were 0.9/100,000 (95% CI 0.1-1.7) and 2.7/100,000 (95% CI 1.7-4.1) inhabitants, respectively. There was a statistically significant increase of CD incidence (p <0.01) during the study period, in contrast to the UC incidence. There were no statistical differences in CARD15 variants over the study period The incidence of CD in North-western Greece has risen disproportionately to that of UC in the 21st century," wrote M. Economou and colleagues, University of Ioannina.

The researchers concluded: "This is not related to alterations of genetic background though."

Economou and colleagues published their study in World Journal of Gastroenterology (Crohn's disease incidence evolution in North-western Greece is not associated with alteration of NOD2/CARD15 variants. World Journal of Gastroenterology, 2007;13(38):5116-20).

For additional information, contact M. Economou, University of Ioannina School of Medicine, 1st Dept. of Internal Medicine and Hepato-gastroenterology Unit, Ioannina 45110, Greece.

Publisher contact information for the World Journal of Gastroenterology is: W J G Press, PO Box 2345, Beijing 100023, People's Republic of China.

Keywords: Greece, Ioannina, Inflammatory Bowel Disease Genetics, Crohn Disease, Gastroenterology, Gastrointestinal, Genetics, Inflammatory Bowel Disease, Ulcerative Colitis.

This article was prepared by Gastroenterology Week editors from staff and other reports. Copyright 2007, Gastroenterology Week via NewsRx.com.