Study findings on fibrosis therapy are outlined in reports from Education and Clinical Center
2007 NOV 19 -- Data detailed in 'Cholinergic mechanisms of cutaneous active vasodilation during heat stress in cystic fibrosis' have been presented. According to recent research from the United States, "To test the hypothesis that cutaneous active vasodilation in heat stress is mediated by a redundant cholinergic cotransmitter system, we examined the effects of atropine on skin blood flow (SkBF) increases during heat stress in persons with (CF) and without cystic fibrosis (non-CF). Vasoactive intestinal peptide (VIP) has been implicated as a mediator of cutaneous vasodilation in heat stress." "VIP-containing cutaneous neurons are sparse in CF, yet SkBF increases during heat stress are normal. In CF, augmented ACh release or muscarinic receptor sensitivity could compensate for decreased VIP; if so, active vasodilation would be attenuated by atropine in CF relative to non-CF. Atropine was administered into skin by iontophoresis in seven CF and seven matched non-CF subjects. SkBF was monitored by laser-Doppler flowmetry (LDF) at atropine treated and untreated sites. Blood pressure [mean arterial pressure (MAP)] was monitored (Finapres), and cutaneous vascular conductance was calculated (CVC=LDF/MAP). The protocol began with a normothermic period followed by a 3-min cold stress and 30-45 min of heat stress. Finally, LDF sites were warmed to 42 degrees C to effect maximal vasodilation. CVC was normalized to its site-specific maximum. During heat stress, CVC increased in both CF and non-CF (p <0.01). CVC increases were attenuated by atropine in both groups (p <0.01); however, the responses did not differ between groups (p=0.99)," wrote D.L. Kellogg and colleagues, Education and Clinical Center. The researchers concluded: "We conclude that in CF there is not greater dependence on redundant cholinergic mechanisms for cutaneous active vasodilation than in non-CF." Kellogg and colleagues published their study in the Journal of Applied Physiology (Cholinergic mechanisms of cutaneous active vasodilation during heat stress in cystic fibrosis. Journal of Applied Physiology, 2007;103(3):963-8). For additional information, contact D.L. Kellogg, Geriatric Research, Dept. of Veterans Affairs, Education and Clinical Center, South Texas Veterans Health Care System, Audie L Murphy Memorial Veterans Hospital Division, San Antonio, TX 78229 USA.. Publisher contact information for the Journal of Applied Physiology is: American Physiological Society, 9650 Rockville Pike, Bethesda, MD 20814, USA. Keywords: United States, San Antonio, Fibrosis Therapy, Applied Physiology, Atropine, Cystic Fibrosis, Drugs, Fibrosis, Genetics, Hepatology, Pharmaceuticals, Pulmonology, Therapy, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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