Study data from University of Thessaloniki, Department of Pediatrics update knowledge of life sciences
2007 NOV 19 -- A report, 'Effect of exocrine pancreatic function on resting energy expenditure in cystic fibrosis,' is newly published data in Acta Paediatrica. In this recently published study, investigators in Greece conducted a study "To prove the hypothesis that exocrine pancreatic function determines resting energy expenditure (REE) in cystic fibrosis (CF) Thirty-eight CF individuals, 9-34 (19.98 ±1.0) years, were divided into three groups: Six pancreatic sufficient patients (PS; group A), 21 pancreatic insufficient patients (PI), whose pulmonary function was comparable to that of group A (group B1) and 11 PI patients, whose pulmonary function was significantly worse than that of group A (group B2). REE was estimated by indirect calorimetry." "Predicted REE was based on Schofield equations. Measured REE was expressed as % of the predicted. BMI, BMI z-scores, serum albumin, cholesterol and triglycerides levels were related to REE. Results were expressed as mean ±standard error Groups B1 and B2 had significantly higher REE% (111.7 ±2.75% and 119.94 ±3.8, respectively) as opposed to group A (98.9 ±3.81%; p=0.022 and 0.035, respectively) whose REE% was similar to that predicted. REE% between group B1 and B2 was not statistically significant. In groups A, B1 and B, mean FEV1% was 86.33 ±10.1%, 90.24 ±4.39%, 44.54 ±3.47%, respectively, mean BMI was 25.6 ±2.06, 19.48 ±0.64 and 20.09 ±8.8, respectively, BMI z-scores were 0.75 ±0.51, -0.52 ±0.24 and -1.07 ±0.37, respectively. Significant correlation was demonstrated between REE%, BMI z-scores and cholesterol levels in group A Clinically stable CF patients, who had comparable pulmonary function, exhibited increased REE% only in the presence of exocrine pancreatic insufficiency. REE% strongly correlated with BMI z-scores in pancreatic sufficiency," wrote T. Moudiou and colleagues, University of Thessaloniki, Department of Pediatrics. The researchers concluded: "These findings support the hypothesis that pancreatic rather than pulmonary function may determine nutritional status as well as REE in CF." Moudiou and colleagues published their study in Acta Paediatrica (Effect of exocrine pancreatic function on resting energy expenditure in cystic fibrosis. Acta Paediatrica, 2007;96(10):1521-5). For additional information, contact T. Moudiou, Aristotle University of Thessaloniki, Second Dept. of Pediatrics, Greece. The publisher of the journal Acta Paediatrica can be contacted at: Taylor & Francis as, Cort Adelersgt 17, PO Box 2562, Solli, 0202 Oslo, Norway. Keywords: Greece, Life Sciences, Pediatrics, Hepatology, Fibrosis, Pulmonology, Genetics, Cystic Fibrosis, Gastroenterology, Pancreas, Serum albumin. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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