Cystic Fibrosis


Research on fibrosis detailed by scientists at Virgen of Rocio University, Department of Internal Medicine



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2007 NOV 13 -- Researchers detail in 'Dynamic colonisation by different Pneumocystis jirovecii genotypes in cystic fibrosis patients,' new data in fibrosis. "Although asymptomatic carriers of Pneumocystis jirovecii with cystic fibrosis (CF) have been described previously, the molecular epidemiology of P. jirovecii in CF patients has not yet been clarified. This study identified the distribution and dynamic evolution of P. jirovecii genotypes based on the mitochondrial large-subunit (mt LSU) rRNA gene," scientists in Seville, Spain report.

"The mt LSU rRNA genotypes of P. jirovecii isolates in 33 respiratory samples from CF patients were investigated using nested PCR and direct sequencing. Three different genotypes were detected: 36.3% genotype 1 (85C/248C); 15.1% genotype 2 (85A/248C); 42.4% genotype 3 (85T/248C); and 6% mixed genotypes," wrote M.A. Montes-Cano and colleagues, Virgen of Rocio University, Department of Internal Medicine.

The researchers concluded: "Patients studied during a 1-year follow-up period showed a continuous colonisation/clearance cycle involving P. jirovecii and an accumulative tendency to be colonised with genotype 3."

Montes-Cano and colleagues published their study in Clinical Microbiology and Infection (Dynamic colonisation by different Pneumocystis jirovecii genotypes in cystic fibrosis patients. Clinical Microbiology and Infection, 2007;13(10):1008-11).

For more information, contact M.A. Montes-Cano, Virgen Del Rocio University Hospital, Dept. of Internal Medicine, Seville, Spain.

Publisher contact information for the journal Clinical Microbiology and Infection is: Blackwell Publishing Ltd., 9600 Garsington Rd., Oxford OX4 2DG, Oxon, England.

Keywords: Spain, Seville, Clinical Microbiology, Cystic Fibrosis, Fibrosis, Genetics, Hepatology, Pneumocystis, Pulmonology.

This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.