Research conducted at Bambino Gesu Children's Hospital has provided new information about pediatric in children
2007 NOV 19 -- Researchers detail in 'Cystinuria in children and young adults: success of monitoring free-cystine urine levels,' new data in life sciences. According to recent research from Rome, Italy, "Medical treatment of cystinuria is often disappointing. Patients undergo frequent surgery, which is often followed by early relapse." "The aim of our study was to evaluate the efficacy of medical treatment of cystinuria, to prevent formation or to reduce the numbers and dimensions of renal stones. Twenty cystinuric patients were treated with a combined approach, including cystine-binding drugs. Free and bound urine cystine levels were measured every 4 months. Drug dosage was adjusted to maintain free urine cystine level below 100 micromol/mmol creatinine. Eighteen patients completed the study; detection of new stones was reduced from 0.28 per year to 0.03 per year, and, in six patients, the numbers and dimensions of pre-existing renal stones were reduced. Surgery was required in one subject, and no relapse was observed 12 months afterwards. The dosage required to achieve target levels was closely correlated with patient body weight: older children required a lower dose. Medical management of cystinuria is feasible," wrote Strologo L. Dello and colleagues, Bambino Gesu Children's Hospital. The researchers concluded: "The treatment must be personalised in children, as the amount of drug required is strictly dependent on body size." Dello and colleagues published their study in Pediatric Nephrology (Cystinuria in children and young adults: success of monitoring free-cystine urine levels. Pediatric Nephrology, 2007;22(11):1869-73). For additional information, contact L. Dello Strologo, Bambino Gesu Children's Hospital and Research Institute, Nephrology and Urology Department, Piazza S Onofrio 4, 00165 Rome, Italy. Publisher contact information for the journal Pediatric Nephrology is: Springer, 233 Spring Street, New York, NY 10013, USA. Keywords: Italy, Rome, Life Sciences, Pediatric, Cystinuria, Treatment, Therapy, Nephrology. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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