Research results from Indiana University update knowledge of renal tubular acidosis
2007 MAY 14 -- Researchers detail in "Renal histopathology of stone-forming patients with distal renal tubular acidosis," new data in renal tubular acidosis. Researchers in the United States conducted a study "To define the renal tissue changes in stone-forming patients with distal renal tubular acidosis (dRTA), we performed intra-operative papillary and cortical biopsies in five patients. The main abnormalities were plugging of inner medullary collecting ducts (IMCD) and Bellini ducts (BD) with deposits of calcium phosphate in the form of apatite; epithelial cell injury and loss was marked." "Plugged ducts were surrounded by interstitial fibrosis, but the fibrosis was generalized, as well, and was a main feature of the histopathology even when plugging was not present. In contrast, common idiopathic calcium oxalate stone formers (SF) never manifest intra-tubule crystals or interstitial fibrosis. Patients with brushite (calcium monohydrogen phosphate) stones and those with cystine stones have many fewer IMCD and BD plugged with apatite (or cystine, in cystinuria), and interstitial fibrosis is limited to the regions around plugged ducts. Patients with dRTA often present a radiographic picture of nephrocalcinosis. Our direct surgical observations reveal that these may be surgically removable stones, especially in patients with well preserved renal function," wrote A.P. Evan and colleagues, Indiana University. The researchers concluded: "In all, dRTA SF have a more diffuse papillary renal disease than other SF thus studied, and are also unusual for the degree of interstitial fibrosis." Evan and colleagues published the results of their research in Kidney International (Renal histopathology of stone-forming patients with distal renal tubular acidosis. Kidney International, 2007;71(8):795-801). For additional information, contact A.P. Evan, Methodist Hospital Institute for Kidney Stone Disease, Methodist Hospital Institute for Kidney Stone Disease, Indiana University, Indianapolis, Indianapolis, Indiana 46223 USA. The publisher of the journal Kidney International can be contacted at: Blackwell Publishing Inc., 350 Main St., Malden, MA 02148, USA. Keywords: United States, Indianapolis, Fibrosis, Hepatology, Kidney, Nephrology, Renal Tubular Acidosis. This article was prepared by Gastroenterology Week editors from staff and other reports. Copyright 2007, Gastroenterology Week via NewsRx.com.
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