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Research Reports from Hospital Clinico Universitario Provide New Insights into Virology

2012 FEB 7 -- Data detailed in "Immunological insights into the pathogenesis of active CMV infection in non-immunosuppressed critically ill patients" have been presented. According to the authors of recent research published in the Journal of Medical Virology, "Dissociation of cytomegalovirus (CMV) DNA loads between the lower respiratory tract and blood, with high levels in the former compartment and low or undetectable levels in the latter, commonly occurs during active CMV infection in critically ill patients despite the presence of high frequencies of CMV-specific IFN-'-producing CD8(+) and CD4(+) T cells in blood. Data presented in this case report suggest that inter-compartmental differences in interleukin-10 (IL-10) levels may, in part, explain the pathobiology of this phenomenon."

"In the absence of ganciclovir treatment, a significant correlation was observed between IL-10 levels and CMV DNA loads in lower respiratory tract specimens (p=0.016), but not in plasma samples (p=0.46). Comparable data were obtained during the course of active CMV infection episodes that developed in six CMV-seropositive critically ill patients with no canonical immunosuppression," wrote J. Blanquer and colleagues, Hospital Clinico Universitario.

The researchers concluded: "The presence of higher levels of IL-10 in the lower respiratory tract than in plasma may result in increased impairment of CMV-specific T-cell effector responses in the lung compared to the systemic compartment, facilitating local CMV replication."

Blanquer and colleagues published their study in the Journal of Medical Virology (Immunological insights into the pathogenesis of active CMV infection in non-immunosuppressed critically ill patients. Journal of Medical Virology, 2011;83(11):1966-71).

For additional information, contact J. Blanquer, Intensive Care Unit, Hospital Clinico Universitario, Valencia, Spain.

Keywords: City:Valencia, Country:Spain, Region:Europe, Respiratory Tract Diseases, Respiratory Tract Infections.

This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2012, Life Science Weekly via NewsRx.com.