Delayed Puberty
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Researchers from St. Jude Children's Research Hospital describe findings in life sciences
2009 MAY 11 - (NewsRx.com) -- Research findings, 'Alterations in pubertal timing following therapy for childhood malignancies,' are discussed in a new report. "The onset of puberty marks a time of rapid linear growth, sexual development, and transition from childhood to maturity. The diagnosis and treatment of a childhood malignancy prior to the onset of puberty has the potential to profoundly affect the timing and the tempo of puberty," scientists in the United States report. "CNS tumors located in the hypothalamic-pituitary (H-P) region, surgical resection in this location, and exposure to CNS radiotherapy are all associated with both precocious and delayed puberty. Also, chemotherapy and radiation can directly damage the gonads, which can result in absent, arrested, or delayed puberty. As a consequence of these alterations of pubertal timing, both male and female survivors of childhood cancer may be at risk of adult short-stature, decreased bone-mineral density, absent or incomplete sexual development, and ultimately, reduced rates of fertility," wrote G.T. Armstrong and colleagues, St. Jude Children's Research Hospital. The researchers concluded: "Appropriate and timely assessment of survivors at high risk of alterations in pubertal development will enable the identification of patients who would benefit from early medical intervention." Armstrong and colleagues published their study in Endocrine Development (Alterations in pubertal timing following therapy for childhood malignancies. Endocrine Development, 2009;15():25-39). For more information, contact G.T. Armstrong, St. Jude Children's Research Hospital, Dept. of Epidemiology and Cancer Control, Memphis, Tenn USA.. Publisher contact information for the journal Endocrine Development is: Springer, 233 Spring Street, New York, NY 10013, USA. Keywords: United States, Memphis, Life Sciences, Delayed Puberty, Drug Therapy, Chemotherapy, Treatment, Endocrine. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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