Dentigerous Cyst
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Studies from Kyushu University have provided new information about cysts
2009 MAY 26 - (NewsRx.com) -- A new study, 'Expression of keratinocyte growth factor and its receptor in odontogenic keratocysts,' is now available. According to a study from Fukuoka, Japan, "The mitotic activity of the epithelial cells of odontogenic keratocysts (OKCs) is greater than that of other odontogenic jaw cysts, and the mitotic activity of the epithelial cells decreases after marsupialization. Keratinocyte growth factor (KGF) interacts with its specific receptor (KGFR), and elicits the proliferation and/or differentiation of the various types of epithelial cells." "The aim of this study was to investigate the expression of KGF/KGFR in OKCs before and after marsupialization. The expression of KGF was immunohistochemically detected in the specimens of 16 OKCs and 11 dentigerous cysts before and after marsupialization. The expression of KGF mRNA was measured in the fibroblasts isolated from OKCs by real-time PCR. KGF was expressed in the epithelial cells and fibroblasts of 12 and seven of 16 OKC specimens, respectively. The intensity of the KGF expression in both the epithelial cells and the fibroblasts significantly decreased after marsupialization. KGFR was expressed throughout the epithelium in 15 of 16 OKC specimens, but the intensity of the KGFR expression did not change after marsupialization. The expression of KGF was detected in the epithelium of two of 11 dentigerous cyst specimens, but not in the fibroblasts before marsupialization. Real-time PCR revealed that recombinant human interleukin (IL)-1alpha increased the expression of KGF mRNA in the fibroblasts isolated from OKCs. KGF/KGFR signaling may play a crucial role in the epithelial cells of OKCs," wrote Y. Suyama and colleagues, Kyushu University. The researchers concluded: "Furthermore, the expression of KGF in the fibroblasts of OKCs is regulated by IL-1alpha." Suyama and colleagues published their study in the Journal of Oral Pathology & Medicine (Expression of keratinocyte growth factor and its receptor in odontogenic keratocysts. Journal of Oral Pathology & Medicine, 2009;38(5):476-80). For more information, contact Y. Suyama, Graduate School of Dental Science, Dept. of Oral and Maxillofacial Surgery, Kyushu University, Fukuoka, Japan. Publisher contact information for the Journal of Oral Pathology & Medicine is: Blackwell Publishing Inc., 350 Main St., Malden, MA 02148, USA. Keywords: Japan, Fukuoka, Dentigerous Cyst, Jaw Cysts, Oral Pathology. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2009, Life Science Weekly via NewsRx.com.
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