Our news journalists obtained a quote from the research from the University of Alabama, "Thus, induction of mucosal immunity through vaccination is a rather difficult task, and potent mucosal adjuvants, vectors or other special delivery systems are often used, especially in the elderly. By taking advantage of the common mucosal immune system, the targeting of mucosal dendritic cells and microfold epithelial cells may facilitate the induction of effective mucosal immunity. Thus, novel routes of immunization and antigen delivery systems also show great potential for the development of effective and safe mucosal vaccines against various pathogens. The purpose of this review is to introduce several recent approaches to induce mucosal immunity to vaccines, with an emphasis on mucosal tissue targeting, new immunization routes and delivery systems."
According to the news editors, the research concluded: "Defining the mechanisms of mucosal vaccines is as important as their efficacy and safety, and in this article, examples of recent approaches, which will likely accelerate progress in mucosal vaccine development, are discussed."
For more information on this research see: Novel vaccine development strategies for inducing mucosal immunity. Expert Review of Vaccines, 2012;11(3):367-79.
The news correspondents report that additional information may be obtained from Y. Fujkuyama, Departments of Pediatric Dentistry and Microbiology, The Immunobiology Vaccine Center, The University of Alabama at Birmingham, Birmingham, AL, United States.
Keywords for this news article include: Alabama, Birmingham, Vaccination, Immunization, United States, Medical Devices, Biological Products, Vaccine Development, North and Central America.
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