Dermatitis Herpetiformis
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Researchers from University of Turku discuss findings in coeliac disease immunology
2009 JUN 1 - (NewsRx.com) -- Scientists discuss in 'Decreased numbers of circulating plasmablasts and differences in IgA1-plasmablast homing to skin in coeliac disease and dermatitis herpetiformis' new findings in coeliac disease. "The two clinical phenotypes of gluten enteropathy, coeliac disease (CD) and dermatitis herpetiformis (DH), were characterized for numbers and homing profiles of circulating final effector B cells, plasmablasts, identified as immunoglobulin (Ig)-secreting cells (ISC). In CD, the numbers of ISC were approximately 50% lower than in DH or controls," researchers in Turku, Finland report. "ISC expressed peripheral lymph node homing receptor (HR), L-selectin, less frequently in CD (54%) and DH (52%) patients than in controls (70%). The expression of gut mucosal HR, alpha(4)beta(7), was less frequent in CD (42%) than in DH (65%) or controls (60%). In DH, but not in CD or controls, a higher proportion of IgA1-ISC (40%) than IgA2-ISC (25%) expressed the skin HR, cutaneous lymphocyte-associated antigen. In gluten enteropathy circulating plasmablasts are more mature, but decreased in number, and have distorted homing profiles," wrote J.M. Kantele and colleagues, University of Turku. The researchers concluded: "Differential IgA1-plasmablast homing could be associated with the development of skin rash with IgA1-deposits in DH but not in CD." Kantele and colleagues published their study in Clinical & Experimental Immunology (Decreased numbers of circulating plasmablasts and differences in IgA1-plasmablast homing to skin in coeliac disease and dermatitis herpetiformis. Clinical & Experimental Immunology, 2009;156(3):535-41). For additional information, contact J.M. Kantele, University of Turku, Dept. of Medical Microbiology and Immunology, Turku, Finland. Publisher contact information for the journal Clinical & Experimental Immunology is: Blackwell Publishing Inc., 350 Main St., Malden, MA 02148, USA. Keywords: Finland, Turku, Coeliac Disease Immunology, Coeliac Disease, Dermatitis Herpetiformis, Dermatology, Gastroenterology, Gluten Enteropathy, Immunology. This article was prepared by Gastroenterology Week editors from staff and other reports. Copyright 2009, Gastroenterology Week via NewsRx.com.
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