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Study data from University of Pavia provide new insights into life sciences
2009 JUL 6 - (NewsRx.com) -- "The protein profiles of bronchoalveolar lavage fluid (BALf) of patients belonging to three selected subsets of Polymyositis/Dermatomyositis (PM/DM) have been compared by using a combination of 2-DE and MALDI-TOF/MS or LC-MS/MS. Our study examined the hypothesis that there were distinct differences in protein expression profiles that were related to the phenotype," scientists in Pavia, Italy report. "From among the 323 +/- 51 protein spots that may represent the most highly expressed proteins in BALf of these patients, 24 unique spots were isolated and proteins identified. In particular, 9 spots were present in BALf of PM/DM patients only; 12 spots were exclusive of Overlap patients and 3 spots of AS patients. From among the proteins identified, a few were classified as cytoskeletal proteins, others were involved in oxidative stress and a number of proteins were associated with general metabolic activity or immunological response and inflammation," wrote I. Passadore and colleagues, University of Pavia. The researchers concluded: "This is the first study in which evidence is provided that a number of different proteins are expressed in different subsets of PM/DM and supports our contention that the proteomic approach would be beneficial in discovering molecules which could represent possible prognostic factors of these rare pathologies.." Passadore and colleagues published their study in the Journal of Proteome Research (2-DE and LC-MS/MS for a Comparative Proteomic Analysis of BALf from Subjects with Different Subsets of Inflammatory Myopathies. Journal of Proteome Research, 2009;8(5):2331-2340). For more information, contact P. Iadarola, University of Pavia, Dept. of Biochemistry, Via Taramelli 3-B, I-27100 Pavia, Italy. Publisher contact information for the Journal of Proteome Research is: American Chemical Society, 1155 16th St., NW, Washington, DC 20036, USA. Keywords: Italy, Pavia, Life Sciences, Rheumatology, Immunology, Dermatomyositis, Polymyositis, Muscular Disease, Protein Expression, Proteomics, Proteins, Biotechnology, Proteome Research, University of Pavia. This article was prepared by Proteomics Weekly editors from staff and other reports. Copyright 2009, Proteomics Weekly via NewsRx.com.
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