DiGeorge Syndrome
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New data from University of Naples illuminate research in digeorge syndrome
2009 MAY 11 - (NewsRx.com) -- "TBX1 haploinsufficiency is considered a major contributor to the del22q11.2/DiGeorge syndrome (DGS) phenotype," scientists in Naples, Italy report. "We have used proteomic tools to look at all the major proteins involved in the TBX1-mediated pathways in an attempt to better understand the molecular interactions instrumental to its cellular functions. We found more than 90 proteins that could be targeted by TBX1 through different mechanisms," wrote M. Caterino and colleagues, University of Naples. The researchers concluded: "The most interesting observation is that overexpression of TBX1 results in down-regulation of two proteins involved in retinoic acid metabolism." Caterino and colleagues published their study in the Journal of Proteome Research (Transcription Factor TBX1 Overexpression Induces Downregulation of Proteins Involved in Retinoic Acid Metabolism: A Comparative Proteomic Analysis. Journal of Proteome Research, 2009;8(3):1515-1526). For more information, contact F. Salvatore, University of Naples Federico 2, Dipartimento Biochim & Biotecnol Medical, Via S Pansini 5, I-80131 Naples, Italy. Publisher contact information for the Journal of Proteome Research is: American Chemical Society, 1155 16th St., NW, Washington, DC 20036, USA. Keywords: Italy, Naples, Biotechnology, DiGeorge Syndrome, Metabolism, Proteome Research, Proteomics, Retinoic Acid, Therapy, Treatment, University of Naples. This article was prepared by Proteomics Weekly editors from staff and other reports. Copyright 2009, Proteomics Weekly via NewsRx.com.
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