Reports from K. Cardona and co-researchers add new data to research in xenotransplantion
2007 NOV 21 -- "Recent advances in human allogeneic islet transplantation have established beta-cell replacement therapy as a potentially viable treatment option for individuals afflicted with Type 1 diabetes. Two recent successes, one involving neonatal porcine islet xenografts transplanted into diabetic rhesus macaques treated with a costimulation blockade-based regimen and the other involving diabetic cynomolgus monkeys transplanted with adult porcine islet xenografts treated with an alternative multidrug immunosuppressive regimen have demonstrated the feasibility of porcine islet xenotransplantation in nonhuman primate models," scientists in the United States report. "In the current study, we assessed whether transplantation of adult porcine islet xenografts into pancreatectomized macaques, under the cover of a costimulation blockade-based immunosuppressive regimen (CD28 and CD154 blockade), could correct hyperglycemia. Our findings suggest that the adult porcine islets transplanted into rhesus macaques receiving a costimulation blockade-based regimen are not uniformly subject to hyperacute rejection, can engraft (2/5 recipients), and have the potential to provide sustained normoglycemia," wrote K. Cardona and colleagues. The researchers concluded: "These results provide further evidence to suggest that porcine islet xenotransplantation may be an attainable strategy to alleviate the islet supply crisis that is one of the principal obstacles to large-scale application of islet replacement therapy in the treatment of Type 1 diabetes." Cardona and colleagues published their study in American Journal of Transplantation (Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways. American Journal of Transplantation, 2007;7(10):2260-2268). For more information, contact C.P. Larsen, Emory Transplant Center, Dept. of Surgery, Atlanta, GA 30322, USA. Publisher contact information for the American Journal of Transplantation is: Blackwell Publishing, 9600 Garsington Rd., Oxford OX4 2DQ, Oxon, England. Keywords: United States, Atlanta, Bioengineering, Xenotransplantion. This article was prepared by Biotech Week editors from staff and other reports. Copyright 2007, Biotech Week via NewsRx.com.
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