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Research from ARUP Institute for Clinical and Experimental Pathology provides new data on chromatography



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This article was published in Life Science Weekly, which you can subscribe to online.
2007 NOV 20 -- Investigators publish new data in the report 'Confirmation of cannabinoids in meconium using two-dimensional gas chromatography with mass spectrometry detection.' "Meconium has become the specimen of choice for determining fetal exposure to drugs of abuse, but its physical complexity can cause interferences from matrix effects. A new method to determine 9-carboxy-11-nor-Delta(9)-THC (9-THCA) and 11-hydroxy-Delta(9)-THC (11-OH-THC) using two-dimensional (2D) GC-MS was developed to reduce interferences and carryover," scientists in the United States report.

"The method was validated using 70 spiked samples prepared in drug-free meconium and 46 residual patient specimens that were confirmed to contain cannabinoids. Ten patient specimens that failed to confirm due to interferences using the previous GC-MS method were analyzed using the new 2D method and 9-THCA was quantitated in all ten samples," wrote S.J. Marin and colleagues, ARUP Institute for Clinical and Experimental Pathology.

The researchers concluded: "The 2D GC-MS method improved chromatography which significantly reduced interferences and carryover when compared to the previous GC-MS method."

Marin and colleagues published their study in the Journal of Chromatography B (Confirmation of cannabinoids in meconium using two-dimensional gas chromatography with mass spectrometry detection. Journal of Chromatography B, 2007;858(1-2):59-64).

For more information, contact S.J. Marin, ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Inc., 500 Chipeta Way, Salt Lake City, UT 84108-1221 USA..

Publisher contact information for the Journal of Chromatography B is: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands.

Keywords: United States, Salt Lake City, Chromatography, Diagnosis, Diagnostics.

This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.