Research data from University Hospital, Department of Paediatrics update understanding of pediatric in children
2007 NOV 19 -- New research, 'Acute decrease of coronary flow after indomethacin delivery in newborn lambs,' is the subject of a report. In this recent report, researchers in Lund, Sweden conducted a study "To document the effects of indomethacin (IND) on coronary flow We studied nine premature lambs during the first day of life. The gestational age varied between 132 and 134 days (term 145 days) and weight 3.1-4.7 kg." "Coronary flow velocities were recorded with an intracoronary Doppler guide wire in the proximal left anterior descending coronary artery (LAD). Average peak flow velocity was measured before, during and after an intravenous IND injection of 0.2 mg per kilogram of body weight IND increased systemic blood pressure (p <0.05) and rate pressure product (RPP; p<0.05) indicating that IND increased cardiac workload. IND decreased coronary average peak flow velocity in all lambs (p <0.05). The maximal fall in coronary velocity appeared after 3 min (range 1-7 min) and was regained 10 min (range 4-53 min) after the drug delivery. The maximal reduction of coronary average peak flow velocity was 52% (median 26)," wrote S. Harling and colleagues, University Hospital, Department of Paediatrics. The researchers concluded: "The recovery time was directly related to the maximal reduction of the coronary average peak flow velocity (R=0.91, R(2) 0.84, p<0.002) Coronary flow velocity decreased markedly in premature born lambs given a bolus dose of IND." Harling and colleagues published their study in Acta Paediatrica (Acute decrease of coronary flow after indomethacin delivery in newborn lambs. Acta Paediatrica, 2007;96(10):1460-3). For additional information, contact S. Harling, University Hospital, Dept. of Paediatrics, Lund, Sweden. Publisher contact information for the journal Acta Paediatrica is: Taylor & Francis as, Cort Adelersgt 17, PO Box 2562, Solli, 0202 Oslo, Norway. Keywords: Sweden, Lund, Life Sciences, Pediatrics, Indomethacin, Pharmaceuticals, Drugs, Therapy, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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