New cell biology study findings have been reported from University of Southern California
2007 NOV 19 -- New research, 'Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives,' is the subject of a report. "Cell penetrating peptides, generally categorized as amphipathic or cationic depending on their sequence, are increasingly drawing attention as a non-invasive delivery technology for macromolecules. Delivery of a diverse set of cargo in terms of size and nature ranging from small molecules to particulate cargo has been attempted using different types of cell penetrating peptides (CPPs) in vitro and in vivo," scientists writing in the journal Pharmaceutical Research report. "However, the internalization mechanism of CPPs is an unresolved issue to date, with dramatic changes in view regarding the involvement of endocytosis as a pathway of internalization. A key reason for the lack of consensus on the mechanism can be attributed to the methodology in deciphering the internalization mechanism. In this review, we highlight some of the methodology concerns, focus more on the internalization pathway and also provide a novel perspective about the intracellular processing of CPPs, which is a crucial aspect to consider when selecting a cell penetrating peptide as a drug delivery system," wrote L.N. Patel and colleagues, University of Southern California. The researchers concluded: "In addition, recent applications of cell penetrating peptides for the delivery of small molecules, peptides, proteins, oligonucleotides, nanoparticles and liposomes have been reviewed." Patel and colleagues published their study in Pharmaceutical Research (Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. Pharmaceutical Research, 2007;24(11):1977-92). Additional information can be obtained by contacting L.N. Patel, University of Southern California, Dept. of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, Los Angeles, California 90089 USA.. The publisher of the journal Pharmaceutical Research can be contacted at: Kluwer Academic, Plenum Publ, 233 Spring St., New York, NY 10013, USA. Keywords: United States, Los Angeles, Cell Biology, Pharmaceuticals. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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