Our news journalists obtained a quote from the research, "We here present an approach relying on dynamic flux balance analysis that allows the integration of metabolic networks at the cellular scale into standardized physiologically-based pharmacokinetic models at the whole-body level. To evaluate our approach we integrated a genome-scale network reconstruction of a human hepatocyte into the liver tissue of a physiologically-based pharmacokinetic model of a human adult. The resulting multiscale model was used to investigate hyperuricemia therapy, ammonia detoxification and paracetamol-induced toxication at a systems level. The specific models simultaneously integrate multiple layers of biological organization and offer mechanistic insights into pathology and medication."
According to the news editors, the research concluded: "The approach presented may in future support a mechanistic understanding in diagnostics and drug development."
For more information on this research see: Integrating cellular metabolism into a multiscale whole-body model. Plos Computational Biology, 2012;8(10):e1002750. (Public Library of Science - www.plos.org; Plos Computational Biology - www.ploscompbiol.org)
Our news journalists report that additional information may be obtained by contacting M. Krauss, Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany.
Keywords for this news article include: Europe, Germany, Leverkusen, Metabolism, Computational Biology.
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