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Research Data from M. Krauss and Colleagues Update Understanding of Computational Biology

2013 JAN 23 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Computational Biology. According to news reporting out of Leverkusen, Germany, by NewsRx editors, research stated, "Cellular metabolism continuously processes an enormous range of external compounds into endogenous metabolites and is as such a key element in human physiology. The multifaceted physiological role of the metabolic network fulfilling the catalytic conversions can only be fully understood from a whole-body perspective where the causal interplay of the metabolic states of individual cells, the surrounding tissue and the whole organism are simultaneously considered."

Our news journalists obtained a quote from the research, "We here present an approach relying on dynamic flux balance analysis that allows the integration of metabolic networks at the cellular scale into standardized physiologically-based pharmacokinetic models at the whole-body level. To evaluate our approach we integrated a genome-scale network reconstruction of a human hepatocyte into the liver tissue of a physiologically-based pharmacokinetic model of a human adult. The resulting multiscale model was used to investigate hyperuricemia therapy, ammonia detoxification and paracetamol-induced toxication at a systems level. The specific models simultaneously integrate multiple layers of biological organization and offer mechanistic insights into pathology and medication."

According to the news editors, the research concluded: "The approach presented may in future support a mechanistic understanding in diagnostics and drug development."

For more information on this research see: Integrating cellular metabolism into a multiscale whole-body model. Plos Computational Biology, 2012;8(10):e1002750. (Public Library of Science - www.plos.org; Plos Computational Biology - www.ploscompbiol.org)

Our news journalists report that additional information may be obtained by contacting M. Krauss, Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany.

Keywords for this news article include: Europe, Germany, Leverkusen, Metabolism, Computational Biology.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC