Researchers' work from National Taiwan University, Graduate Institute focuses on drug resistance
2007 NOV 19 -- Investigators publish new data in the report 'Prognosis of adult patients with bacteremia caused by extensively resistant Acinetobacter baumannii.' According to recent research from Taipei, Taiwan, "Nosocomial bacteremia caused by extensively resistant Acinetobacter baumannii (ERAB) is an emerging problem in Taiwanese hospitals. Accordingly, we retrospectively investigated the epidemiology and outcomes of adult patients with ERAB bacteremia (ERABB) after different treatments from January 2001 to September 2004 at the National Taiwan University Hospital, Taipei, Taiwan." "A total of 56 adult patients with ERABB and without other simultaneous infections were enrolled. Demographic, clinical, and laboratory data were obtained from medical records. Clinical data included underlying diseases and conditions with onset within 7 days after ERABB, severity of ERABB, antibiotic regimens for ERABB, and clinical outcomes. Laboratory data included hemograms, liver function tests, renal function tests, and albumin levels. Coagulation profiles were obtained at ERABB onset and 7 days before and after onset. All 56 episodes of ERABB were hospital-acquired. Most patients had Acute Physiology Scores and Chronic Health Evaluation II scores >/=17 (66.1%) and Pitt bacteremia score >/=4 (66.1%). Many had comorbid diseases at ERABB onset. Crude mortality rates on days 2, 7, 15, 30, and at discharge were 23.2%, 30.4%, 37.5%, 48.2%, and 60.7%, respectively. High severity of ERABB (Pitt bacteremia score >/=4) and presence of immunosuppression were the only 2 predictors for day 30 mortality (odds ratios of 18.53 and 8.06, respectively)," wrote Y.C. Tseng and colleagues, National Taiwan University, Graduate Institute. The researchers concluded: "Antibiotic regimens for ERABB did not have a significant influence on ERABB outcomes." Tseng and colleagues published their study in Diagnostic Microbiology and Infectious Disease (Prognosis of adult patients with bacteremia caused by extensively resistant Acinetobacter baumannii. Diagnostic Microbiology and Infectious Disease, 2007;59(2):181-90). For additional information, contact Y.C. Tseng, Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan. Publisher contact information for the journal Diagnostic Microbiology and Infectious Disease is: Elsevier Science Inc., 360 Park Avenue South, New York, NY 10010-1710, USA. Keywords: Taiwan, Taipei, Antimicrobial Resistance, Bacteremia, Diagnostics, Drug Resistance, Microbiology, Therapy, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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