Research results from P.G. Rossi and co-authors update knowledge of drug resistance
2007 NOV 19 -- "The essential oil of wild Daucus carota L. obtained from aerial parts at the end of the flowering stage (DCEO) was reported as antimicrobial against the human enteropathogen Campylobacter jejuni. The aim of the present study was to extend this analysis to other Campylobacter species and to identify the active compounds of the essential oil, subjected to GC, GC-MS, and C-13 NMR analysis," scientists in Corte, France report. "A minimum inhibitory concentration assay was used to quantify the antimicrobial activity of DCEO and the major components, isolated on column chromatography. Growth of all the C. jejuni, Campylobacter coli, and Campylobacter lari strains tested, including one multidrug resistant C. jejuni, was inhibited to the same extent by DCEO. Molecules that were responsible for the antibacterial activity were identified as (E)-methylisoeugenol and elemicin," wrote P.G. Rossi and colleagues. The researchers concluded: "Moreover, the use of structural analogues of these compounds allowed us to identify important features that may account for the activity." Rossi and colleagues published their study in the Journal of Agricultural and Food Chemistry ((E)-methylisoeugenol and elemicin: Antibacterial components of Daucus carota L. essential oil against Campylobacter jejuni. Journal of Agricultural and Food Chemistry, 2007;55(18):7332-7336). For additional information, contact A. Luciani, University of Corse, CNRS, UMR 6134, Laboratory Chim Produits Nat Laboratory Biochim & Biology Molecular Vege, BP 52, F-20250 Corte, France. The publisher's contact information for the Journal of Agricultural and Food Chemistry is: American Chemical Society, 1155 16th St., NW, Washington, DC 20036, USA. Keywords: France, Corte, Antimicrobial Resistance, Drug Resistance, Therapy, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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