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Study results from J. Kopeckapilarczyk et al provide new insights into biochemistry
2009 JUN 8 - (NewsRx.com) -- According to a study from Oporto, Portugal, "In our previous studies we assessed the biochemical response of juvenile seabream to the exposure to three selected polycyclic aromatic hydrocarbons (PAHs) (phenanthrene, pyrene and fluorene) in short-term laboratory experiments. Since in the analyses conducted in the field it is much more natural to expect the presence of multiple contaminants at the same time, the objective of this study was to analyse the reaction of seabream to the exposure to a mix of the three PAHs tested previously." "The proportions of the individual components in the PAH mix used in our experiments were constant and determined on the basis of the concentration addition concept. We measured a set of hepatic biomarkers: 7-ethoxyresorufin-O-deethylase (EROD), glutathione-S-transferase (GST), catalase (CAT), superoxide dismutase (SOD) and lipid peroxidation; as well as biliary fluorescent aromatic compounds (FACs) metabolites. Moreover, we calculated the biotransformation index, the condition factor and the hepatosomatic index. Only a few of these indicators provided statistically significant response to the tested exposures, while FACs showed very strong increase with increasing concentration of the tested mix of PAHs," wrote J. Kopeckapilarczyk and colleagues. The researchers concluded: "The results of this research are expected to contribute to the establishment of a good biochemical index of exposure to mixtures of PAHs in laboratory experiments, which can be further useful in field studies dealing with the impact of organic pollutants on marine organisms." Kopeckapilarczyk and colleagues published the results of their research in Ecotoxicology and Environmental Safety (Biochemical response in gilthead seabream (Sparus aurata) to in vivo exposure to a mix of selected PAHs. Ecotoxicology and Environmental Safety, 2009;72(4):1296-1302). For additional information, contact J. Kopeckapilarczyk, CIIMAR Center Marine Environmental Research, Laboratory Environmental Toxicology, Rua Bragas 289, P-4050123 Oporto, Portugal. The publisher of the journal Ecotoxicology and Environmental Safety can be contacted at: Academic Press Inc. Elsevier Science, 525 B St., Ste. 1900, San Diego, CA 92101-4495, USA. Keywords: Portugal, Oporto, Biochemistry, Biochemical, Deethylase, Dietary Supplement, Enzyme Research, Glutathione, Micronutrient. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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