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"Dermatological Treatment Methods and Formulations" in Patent Application Approval Process

2013 JAN 15 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Law Weekly -- A patent application by the inventors Stockel, Richard F. (Bridgewater, NJ); Sawyer, Anthony J. (Albuquerque, NM); Winston, Anthony E. (East Brunswick, NJ), filed on August 31, 2012, was cleared for further review on January 3, 2013, according to news reporting originating from Washington, D.C., by NewsRx correspondents.

Patent serial number 600935 is assigned to Nevada Naturals, Inc.

The following quote was obtained by the news editors from the background information supplied by the inventors: "The prior art is replete with various approaches to the treatment of dermatological conditions. Benzoyl peroxide is well known as a medicament for the treatment of acne. Often the benzoyl peroxide is combined with an antibacterial agent or an antibiotic to extend its spectrum of activity as disclosed in, e.g., U.S. Pat. No. 5,767,098. However there are several disadvantages to this combination approach. With prolonged usage that is typically required for the treatment of acne, the bacterial flora becomes resistant thus rendering the antibacterial agent or the antibiotic less effective in subsequent treatment. Moreover, the benzoyl peroxide component of the combination is oxidatively unstable.

"Numerous publications and patents disclose the use of alpha.-hydroxy acids for the treatment of dermatological conditions. For example, U.S. Pat. No. 4,363,815 discloses the use of such compounds for the treatment of dry skin, ichthyosis, plantar hyperkeratosis, Darier's disease, keratoses, acne, psoriasis, eczema, pruritis, warts and herpes virus. Other patents describe the use of various incipients to lessen skin irritation and stinging, e.g., lactate salts, amphoteric salts (see U.S. Pat. No. 5,420,106), ascorbic acid derivatives (U.S. Pat. No. 5,703,122), amino salts (see Cosmetics and Toiletries, volume 113, March 1998, p. 55). However alpha-hydroxyl acids and the above mentioned incipients are not primarily used to cure skin infections but to remove dead keratin.

"Salicylic acid is frequently disclosed as an active ingredient for the treatment of a wide variety of skin conditions, e.g., psoriasis, skin atrophy, skin wrinkles, acne, etc., see U.S. Pat. Nos. 5,776,920; 5,780,457; 5,780,458; 6,436,417. In all of these cases, salicylic acid must be modified with other incipients to prevent undesirable side reactions such as skin irritation and the like.

"There is a need for a safe and efficacious course of treatment for severe acne, especially that which gets at the root cause of skin problems due to bacterial infections. Antibiotics such are sometimes prescribed for treating acne. However, there are potential side effects to antibiotic treatment including subsequent resistance to the effectiveness of antibiotics when needed to treat this and other diseases. The only treatment to date which has proven to be effective for non-bacterial infections is isotretinoin which is orally administered. This medication has many undesirable side effects including the possibility of causing birth defects when administered to pregnant women."

In addition to the background information obtained for this patent application, NewsRx journalists also obtained the inventors' summary information for this patent: "This invention pertains to a novel method of using the dermatological compositions of this invention. The compositions comprise a salt of a monomeric or polymeric cation and a monomeric or polymeric carboxylate anion. This invention also pertains to dermatological formulations for treating mammalian skin, or nails comprising a salt of a monomeric or polymeric cation and a carboxylate anion. The dermatological salts of the invention preferably are strongly adherent to the surface of the skin. The cation of the salt may be an amidinium, a guanidinium, or a biguanidinium, or a quaternary ammonium cation, while the anion may be a carboxylate. The cation may also be an amine acid salt of an azole. The cation may also be a cation of an antibiotic with an amine functional group. Such compositions possess antimicrobial, antibacterial, antifungal, and antiviral properties. In addition they may have mammalian skin or nail-beneficial properties."

URL and more information on this patent application, see: Stockel, Richard F.; Sawyer, Anthony J.; Winston, Anthony E. Dermatological Treatment Methods and Formulations. U.S. Patent Serial Number 600935, filed August 31, 2012, and posted January 3, 2013. Patent URL: http://appft.uspto.gov/netacgi/nph-Parser'Sect1=PTO2&Sect2=HITOFF&u=%2Fnetahtml%2FPTO%2Fsearch-adv.html&r=3062&p=62&f=G&l=50&d=PG01&S1=20121227.PD.&OS=PD/20121227&RS=PD/20121227

Keywords for this news article include: Drugs, Therapy, Electrolytes, Legal Issues, Acne Vulgaris, Benzoic Acids, Topical Agents, Benzoyl Peroxide, Inorganic Chemicals, Topical Acne Agents, Nevada Naturals Inc., Dermatological Agents, Reactive Oxygen Species, Bacterial Infections and Mycoses.

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