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New pathology study results reported from Colorado State University
2009 AUG 18 - (NewsRx.com) -- According to a study from the United States, "The implantation of synthetic biomaterials initiates the foreign body response (FBR), which is characterized by macrophage infiltration, foreign body giant cell formation, and fibrotic encapsulation of the implant. The FBR is orchestrated by a complex network of immune modulators, including diverse cell types, soluble mediators, and unique cell surface interactions." "The specific tissue locations, expression patterns, and spatial distribution of these immune modulators around the site of implantation are not clear. This study describes a model for studying the FBR in vivo and specifically evaluates the spatial relationship of immune modulators. We modified a biomaterials implantation in vivo model that allowed for cross-sectional in situ analysis of the FBR. Immunohistochemical techniques were used to determine the localization of soluble mediators, ie, interleukin (11)4, IL-13, IL-10, IL-6, transforming growth factor-beta, tumor necrosis factor-alpha, interferon-gamma, and MCP-1; specific cell types, ie, macrophages, neutrophils, fibroblasts, and lymphocytes; and cell surface markers, ie, F4/80, CD11b, CD11c, and Ly-6C, at early, middle, and late stages of the FBR in subcutaneous implant sites. The cytokines IL-4, IL-13, IL-10, and transforming growth factor-beta were localized to implant-adherent cells that included macrophages and foreign body giant cells," wrote D.M. Higgins and colleagues, Colorado State University. The researchers concluded: "A better understanding of the FBR in vivo will allow the development of novel strategies to enhance biomaterial implant design to achieve better performance and safety of biomedical devices at the site of implant. (Am J Pathol 2009, 175:161-170; DOI: 10.2353/ajpath.2009.080962)." Higgins and colleagues published their study in American Journal of Pathology (Localized Immunosuppressive Environment in the Foreign Body Response to Implanted Biomaterials. American Journal of Pathology, 2009;175(1):161-170). For more information, contact D.M. Higgins, Colorado State University, Dept. of Microbiology Immunology & Pathology, Fort Collins, CO 80523, USA. Publisher contact information for the American Journal of Pathology is: American Society Investigative Pathology, Inc., 9650 Rockville Pike, Bethesda, MD 20814-3993, USA. Keywords: United States, Fort Collins, Life Sciences, Pathology, Colorado State University. This article was prepared by Science Letter editors from staff and other reports. Copyright 2009, Science Letter via NewsRx.com.
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