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Researchers from National Institutes of Health detail findings in HIV/AIDS
2009 AUG 24 - (NewsRx.com) -- "The Nef protein of human immunodeficiency virus type 1 downregulates the CD4 coreceptor from the surface of host cells by accelerating the rate of CD4 endocytosis through a clathrin/AP-2 pathway. Herein, we report that Nef has the additional function of targeting CD4 to the multivesicular body (MVB) pathway for eventual delivery to lysosomes," scientists in the United States report. "This targeting involves the endosomal sorting complex required for transport (ESCRT) machinery. Perturbation of this machinery does not prevent removal of CD4 from the cell surface but precludes its lysosomal degradation, indicating that accelerated endocytosis and targeting to the MVB pathway are separate functions of Nef," wrote L.L.P. Dasilva and colleagues, National Institutes of Health. The researchers concluded: "We also show that both CD4 and Nef are ubiquitinated on lysine residues, but this modification is dispensable for Nef-induced targeting of CD4 to the MVB pathway.." Dasilva and colleagues published their study in the Journal of Virology (Human Immunodeficiency Virus Type 1 Nef Protein Targets CD4 to the Multivesicular Body Pathway. Journal of Virology, 2009;83(13):6578-6590). For additional information, contact J.S. Bonifacino, Eunice Kennedy Shriver National Institute Child Health & Hum, Cell Biology & Metab Program, National Institutes of Health, Bldg 18T, Room 101, Bethesda, MD 20892, USA. The publisher's contact information for the Journal of Virology is: American Society Microbiology, 1752 N St. NW, Washington, DC 20036-2904, USA. Keywords: United States, Bethesda, HIV/AIDS, AIDS, Acquired Immune Deficiency Syndrome, Endocytosis, HIV, Human Immunodeficiency Virus, Immunology, Sexually Transmitted Disease, Viral, Virology, National Institutes of Health. This article was prepared by AIDS Weekly editors from staff and other reports. Copyright 2009, AIDS Weekly via NewsRx.com.
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