Fallopian Tube Cancer
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Researchers from University of Texas provide details of new studies and findings in the area of squamous cell carcinoma
2009 MAY 11 - (NewsRx.com) -- "Squamous cell carcinoma (SCC) of the fallopian tube is rare and often diagnosed postoperatively. Cervical cancer is considered as a long-term sequaele, resulting from sexual transmitted infection with certain common high-risk human papilloma virus (HPV) types," researchers in the United States report. "The role of human papilloma virus in the development of the tubal SCC is unknown. We report an unusual case of SCC of the fallopian tube, synchronously occurring with cervical SCC in situ in a 49-year-old patient. Histological examination of the entire endometrium revealed no involvement. Both tubal and cervical lesions showed the presence of high risk HPV 16 by PCR and increased expression of p16(INK4a) protein. Both SCC of the fallopian tube and cervical SCC in situ were positive for p63, while the non-involved tubal epithelium was positive for WT-1, but negative for p63," wrote Z.Q. Wang and colleagues, University of Texas. The researchers concluded: "The concomitant occurrence of fallopian tube and cervical SCC can be explained by: (i) the 'field effect' of HPV infection resulting in the concomitant development of primary SCC in various sites of the female genital tract; (ii) the primary fallopian tube SSC metastasizing to the uterine cervix; or (iii) primary cervical SCC metastasizing to the fallopian tube. The detection of HPV 16 and p16(INK4a) in both the fallopian tube and cervical SCCs strengthens the hypothesis of the 'field effect' of HPV infection." Wang and colleagues published their study in the Journal of Obstetrics and Gynaecology Research (Detection of human papilloma virus subtypes 16 and P16(Ink4a) in invasive squamous cell carcinoma of the fallopian tube and concomitant squamous cell carcinoma in situ of the cervix. Journal of Obstetrics and Gynaecology Research, 2009;35(2):385-389). For additional information, contact S.M. Qiu, University of Texas Med Branch, Dept. of Pathology, 2-190 John Sealy Annex, 301 University Blvd., Galveston, TX 77555, USA. Publisher contact information for the Journal of Obstetrics and Gynaecology Research is: Wiley-Blackwell Publishing, Inc., Commerce Place, 350 Main St., Malden 02148, MA, USA. Keywords: United States, Galveston, Carcinoma in Situ, Cervical Cancer, Cervical Carcinoma, Fallopian Tube Cancer, Fallopian Tube Carcinoma, Gynecology, Human Papilloma Virus, Obstetrics, Oncology, Papilloma, Squamous Cell Carcinoma, Viral Research, Virology, Women's Health, University of Texas. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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