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Recent studies by H. Kayadibi and co-authors add new data to alcoholism findings
2009 AUG 17 - (NewsRx.com) -- "Determination of the liver histological lesions with noninvasive tests is an important part of the diagnostic work-up of patients with non-alcoholic fatty liver disease (NAFLD). We aimed to determine the predictive value of noninvasive biochemical markers, serum prolidase enzyme activity (SPEA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and AST/ALT ratio for the liver histological lesions," scientists in Turkey report. "Fifty-four liver biopsy-proven patients with NAFLD and 37 healthy controls were enrolled to the study. The diagnostic accuracies of biochemical markers were evaluated by receiver operating characteristic (ROC) curves and multiple linear regression analysis to predict the degree of fatty infiltration, lobular inflammation, NAFLD activity score, and stage of fibrosis. The SPEA of patients with steatohepatitis is significantly increased compared with the patients with simple steatosis and controls (1,338 [1,138-1,624] U/l; 974 [768-1,160] U/l; 972 [862-1,122] U/l, shown as median [25th-75th interquartile range], respectively, P< 0.0001). SPEA was positively correlated with the grade of liver fatty infiltration, lobular inflammation and NAFLD activity score, and stage of fibrosis, (r = 0.377, P< 0.005; r = 0.443, P< 0.001; r = 0.457, P< 0.001; r = 0.321, P< 0.018, respectively). SPEA was the best predictor for distinguishing steatohepatitis from simple steatosis according to the ROC analysis (area under the curve [AUC]: 0.85). Multivariate analysis revealed that the most useful single test for predicting lobular inflammation, NAFLD activity score, and fibrosis was SPEA, and for predicting the fatty infiltration, it was ALT (P < 0.00001, P< 0.001, P< 0.0001, P< 0.0001, respectively). This study demonstrated that SPEA can accurately predict the degree and stage of all histological lesions in NAFLD," wrote H. Kayadibi and colleagues. The researchers concluded: "It could be helpful for distinguishing steatohepatitis from simple steatosis and reducing the need for liver biopsy in the majority of patients with NAFLD.." Kayadibi and colleagues published their study in Digestive Diseases and Sciences (Diagnostic Value of Serum Prolidase Enzyme Activity to Predict the Liver Histological Lesions in Non-alcoholic Fatty Liver Disease: A Surrogate Marker to Distinguish Steatohepatitis from Simple Steatosis. Digestive Diseases and Sciences, 2009;54(8):1764-1771). For additional information, contact H. Kayadibi, Ardahan Military Hospital, Dept. of Biochemistry & Clinic Biochemistry, Ardahan, Turkey. The publisher's contact information for the journal Digestive Diseases and Sciences is: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. Keywords: Turkey, Addiction Medicine, Alcoholism, Aminotransferase, Biochemical, Biopsy, Diagnostics, Digestive Diseases, Enzyme Research, Fatty Liver, Gastroenterology, Hepatology, Inflammation, Liver Cirrhosis, Liver Disease, Liver Fibrosis, Mental Health, Steatosis, Surgery. This article was prepared by Gastroenterology Week editors from staff and other reports. Copyright 2009, Gastroenterology Week via NewsRx.com.
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