Fetal Growth Retardation
Return to Library
|
Free Fetal Growth Retardation Articles |
|
|
|
|
Studies from Hospital for Special Surgery further understanding of coagulation
2009 JUN 8 - (NewsRx.com) -- "Pregnancy loss and intrauterine growth restriction (IUGR) are serious pregnancy complications, and the triggers and mediators of placental and fetal damage are not completely understood. Using a mouse model of recurrent spontaneous miscarriages (DBA/2-mated CBA/J mice) that shares features with human recurrent miscarriage and fetal growth restriction, we identified tissue factor (TF) as an essential participating factor in placental and fetal injury," scientists writing in the journal Blood report. "We have previously shown that C5a releases antiangiogenic molecule sFlt-1 in monocytes that causes defective placental development and fetal death in DBA/2-mated CBA/J mice. In this study, we found that TF not only activates the coagulation pathway, but it also mediates sFlt-1 release in monocytes causing defective placental development and fetal death. Blockade of TF with a monoclonal antibody inhibited sFlt-1 release, prevented the pathological activation of the coagulation pathway, restored placental blood flow, prevented placental oxidative stress, and rescued pregnancies. We also demonstrated that pravastatin, by down-regulating TF expression on monocytes and trophoblasts, prevented placental damage and protected pregnancies in DBA/2-mated CBA/J mice," wrote P. Redecha and colleagues, Hospital for Special Surgery. The researchers concluded: "These studies indicate that TF is an important mediator in fetal death and growth restriction and that statins may be a good treatment for women with recurrent miscarriages and IUGR. (Blood. 2009; 113:4101-4109)'." Redecha and colleagues published their study in Blood (Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury. Blood, 2009;113(17):4101-4109). Additional information can be obtained by contacting G. Girardi, Hospital for Special Surgery, 535 E 70th St., New York City, NY 10021, USA. The publisher of the journal Blood can be contacted at: American Society Hematology, 1900 M Street. NW Suite 200, Washington, DC 20036, USA. Keywords: United States, New York, Coagulation, Drugs, Fetal Growth Retardation, Obstetrics, Pharmaceuticals, Pravastatin Sodium, Pregnancy Complications, Spontaneous Abortion, Surgery, Therapy, Treatment, Hospital for Special Surgery. This article was prepared by Hematology Week editors from staff and other reports. Copyright 2009, Hematology Week via NewsRx.com.
|
