Fibrinolysis
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Data from Brussels Free University advance knowledge in coagulation
2009 JUL 27 - (NewsRx.com) -- "Serine protease inhibitors (serpins) are a structurally related but functionally diverse family of ubiquitous proteins. We previously described Ixodes ricinus immunosuppressor (Iris) as a serpin from the saliva of the tick I. ricinus displaying high affinity for human leukocyte elastase," scientists writing in the Febs Journal report. "Iris also displays pleotropic effects because it interferes with both the immune response and hemostasis of the host. It thus inhibits lymphocyte proliferation and the secretion of interferon-gamma or tumor necrosis factor-alpha by peripheral blood mononuclear cells, and also platelet adhesion, coagulation and fibrinolysis. Its ability to interfere with coagulation and fibrinolysis, but not platelet adhesion, depends on the integrity of its antiproteolytic reactive center loop domain. Here, we dissect the mechanisms underlying the interaction of recombinant Iris with peripheral blood mononuclear cells. We show that Iris binds to monocytes/macrophages and inhibits their ability to secrete tumor necrosis factor-alpha. Recombinant Iris also has a protective role in endotoxemic shock. The anti-inflammatory ability of Iris does not depend on its antiprotease activity," wrote P.P. Prevot and colleagues, Brussels Free University. The researchers concluded: "Moreover, we pinpoint the exosites involved in this activity.." Prevot and colleagues published their study in Febs Journal (Exosites mediate the anti-inflammatory effects of a multifunctional serpin from the saliva of the tick Ixodes ricinus. Febs Journal, 2009;276(12):3235-3246). Additional information can be obtained by contacting E. Godfroid, Brussels Free University, IBMM, Laboratory Biology Mole & Ectoparasites, Rue Prof Jeener & Brachet 12, B-6041 Gosselies, Belgium. The publisher of the Febs Journal can be contacted at: Wiley-Blackwell Publishing, Inc., Commerce Place, 350 Main St., Malden 02148, MA, USA. Keywords: Belgium, Gosselies, Antiinflammatory, Bloodstream Infection, Coagulation, Elastase, Enzyme Research, Enzymology, Fibrinolysis, Immunology, Interferon, Interferon Gamma, Necrosis, Protease Inhibitors, Sepsis, Septicemia, Therapy, Treatment, Brussels Free University. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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