Fibrosarcoma
Return to Library
|
Free Fibrosarcoma Articles |
|
|
|
|
Researchers from Comenius University, Institute of Pathophysiology provide details of new studies and findings in the area of cancer immunology
2009 JUN 29 - (NewsRx.com) -- Fresh data on cancer are presented in the report 'Brain response to induced peripheral cancer development in rats: dual fos-tyrosine hydroxylase and fos-oxytocin immunohistochemistry.' "During last few decades a considerable number of data has emerged supporting the hypothesis that central nervous system might monitor and modulate tumor growth. This assumption is based on two facts: 1. immune system plays a crucial role in the development and progression of cancer; 2. immune and nervous systems communicate tightly and bidirectionally," scientists in Bratislava, Slovakia report. "The aim of present study was to elucidate whether tumor growth may induce detectable changes in brain structures that are involved in the response to immune challenges. Using Fos immunohistochemistry, we investigated whether the advanced stage of cancer, induced by a single intraperitoneal injection of BP6-TU2 fibrosarcoma cells to male Wistar rats, could activate Fos expression in the nucleus of the solitary tract (NTS), amygdala and parabrachial nuclei (PBN) and also activate some of neuronal phenotypes including tyrosine hydroxylase (TH) neurons in the brainstem noradrenergic cell groups and hypothalamic oxytocinergic neurons. Twenty eight days after the initiation of tumor process we found increased Fos expression in NTS/A2, A1 noradrenergic cells, PBN as well as in the hypothalamic paraventricular, supraoptic and accessory oxytocinergic neurons. These structures are involved in the transmission of signals related to immune challenges within the brain and consequent elaboration of neuro-endocrine responses. The data obtained are supporting the view that the information on peripheral tumor development might be transmitted to the brain," wrote B. Mravec and colleagues, Comenius University, Institute of Pathophysiology. The researchers concluded: "However, further studies are necessary to be performed to reveal whether our findings can be attributed to specific effect of cancer or whether observed changes in the activity of brainstem and hypothalamic neurons reflex processes that only accompany the cancer progression." Mravec and colleagues published their study in Endocrine Regulations (Brain response to induced peripheral cancer development in rats: dual fos-tyrosine hydroxylase and fos-oxytocin immunohistochemistry. Endocrine Regulations, 2009;43(1):3-11). For additional information, contact B. Mravec, Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic. The publisher's contact information for the journal Endocrine Regulations is: Springer, 233 Spring Street, New York, NY 10013, USA. Keywords: Slovakia, Bratislava, Cancer Immunology, Cancer, Dermatology, Drugs, Endocrine, Enzyme Research, Fibrosarcoma, Hydroxylase, Immunology, Oncology, Oxytocin, Pharmaceuticals, Physiology, Therapy, Treatment. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
|
