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Findings from T. Riordan and co-authors broaden understanding of lemierre's syndrome therapy
2007 NOV 12 -- New investigation results, 'Human infection with Fusobacterium necrophorum (Necrobacillosis), with a focus on Lemierre's syndrome,' are detailed in a study published in Clinical Microbiology Reviews. "Human infection with Fusobacterium necrophorum usually involves F. necrophorum subsp. funduliforme rather than F. necrophorum subsp. necrophorum, which is a common pathogen in animals. Lemierre's syndrome, or postanginal sepsis, is the most common life-threatening manifestation," scientists in Exeter, the United Kingdom report. "Tonsillitis is followed by septic thrombophlebitis of the internal jugular vein and then a septicemia with septic emboli in lungs and other sites. Recent evidence suggests that F. necrophorum can be limited to the throat and cause persistent or recurrent tonsillitis. F. necrophorum is unique among non-spore-forming anaerobes, first for its virulence and association with Lemierre's syndrome as a monomicrobial infection and second because it seems probable that it is an exogenously acquired infection. The source of infection is unclear; suggestions include acquisition from animals or human-to-human transmission. Approximately 10% of published cases are associated with infectious mononucleosis, which may facilitate invasion. Recent work suggests that underlying thrombophilia may predispose to internal jugular vein thrombophlebitis. Lemierre's syndrome was relatively common in the preantibiotic era but seemed to virtually disappear with widespread use of antibiotics for upper respiratory tract infection," wrote T. Riordan and colleagues, . The researchers concluded: "In the last 15 years there has been a rise in incidence, possibly related to restriction in antibiotic use for sore throat." Riordan and colleagues published their study in Clinical Microbiology Reviews (Human infection with Fusobacterium necrophorum (Necrobacillosis), with a focus on Lemierre's syndrome. Clinical Microbiology Reviews, 2007;20(4):622-59). For more information, contact T. Riordan, Royal Devon & Exeter Foundation Trust, Microbiology Department, Exeter, UK. Publisher contact information for the journal Clinical Microbiology Reviews is: American Society Microbiology, 1752 N St. NW, Washington, DC 20036-2904, USA. Keywords: United Kingdom, Exeter, Lemierre's Syndrome Therapy, Angiology, Clinical Microbiology, Fusobacterium, Infectious Disease, Infectious Mononucleosis, Internal Jugular Vein, Lemierre's Syndrome, Otolaryngology, Pharyngitis, Respiratory Tract Infections, Therapy, Tonsillitis, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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