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Findings from Federal University of Minas Gerais provide new insights into biotechnology
2009 AUG 24 - (NewsRx.com) -- "The biotransformation of 1R-(-)-camphorquinone, achieved by growing cells of four fungi species isolated from soil (Mucor plumbeus, Lecanicillium muscarium, Thamnostylum sp. and Syncephalastrum racemosum), was investigated in optimized culture media for each species. Fungi were grown aerobically under shaking and their activities with respect to camphorquinone were monitored for 20 days by gas chromatography coupled to mass spectrometry (GCMS)," investigators in Belo Horizonte, Brazil report. "Camphorquinone was found to be stable in control flasks throughout the experiment. The most interesting results were found for M. plumbeus, which was only able to perform monoreduction of camphorquinone when cultivated on a glucose-peptone-yeast extract medium. Large-scale experiments were set up and the camphorquinone biotransformation products formed by M. plumbeus were purified by column chromatography and identified by H-1 and C-13 nuclear magnetic resonance (NMR)," wrote G.G. Desouza and colleagues, Federal University of Minas Gerais. The researchers concluded: "Theoretical calculations were employed as a complementary technique to unambiguously identify the biotransformation products. that M. plumbeus could be of great use for the selective reduction of camphorquinone and related compounds.." Desouza and colleagues published their study in the Journal of Industrial Microbiology & Biotechnology (Selective activity of Mucor plumbeus reductase towards (-)-camphorquinone. Journal of Industrial Microbiology & Biotechnology, 2009;36(8):1023-1027). For additional information, contact J.A. Takahashi, Federal University of Minas Gerais, Dept. of Quim, ICEx, Campus University, BR-31270901 Belo Horizonte, MG, Brazil. The publisher of the Journal of Industrial Microbiology & Biotechnology can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. Keywords: Brazil, Belo Horizonte, Life Sciences, Diagnosis, Diagnostics, Biotechnology, Mass Spectrometry, Chromatography, Industrial Microbiology & Biotechnology, Federal University of Minas Gerais. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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