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Researchers from Sun Yat-Sen University, Department of Anatomy detail findings in helicobacter pylori in children
2009 AUG 24 - (NewsRx.com) -- Fresh data on helicobacter pylori are presented in the report 'Distinctiveness of the cagA genotype in children and adults with peptic symptoms in South China.' According to recent research published in the journal Helicobacter, "Helicobacter pylori infection is different between children and adults, not only in infection rate but also in virulence genotypes. However, the 3' region of CagA, important in stomach carcinogenesis, still remains unclear in children." "The present study aims to compare the frequency of cagA and the distribution of its subtypes between children and adults in South China. One hundred and twenty-eight children and 99 adults with peptic symptoms were enrolled in our research. Histology, rapid urease test, and real-time polymerase chain reaction (PCR) assay were used to diagnose H. pylori infection. vacA s1 was detected by real-time PCR, and EPIYA motifs in the 3' region of CagA by conventional PCR and DNA sequencing. H. pylori infection was diagnosed in 53 children and 62 adults. vacA s1 was identified in 90.6% and 91.9% of infected children and adults, respectively. Furthermore, cagA was identified in 73.6% and 82.3% of infected children and adults, respectively. No patient with multiple cagA subtypes was observed. A higher prevalence of more virulent cagA genotype was found in children compared to adults (p <.05). Thirty-eight of 39 (97.4%) cagA-positive children were found to have EPIYA-ABD and only one (2.6%) with EPIYA-ABC. In adults, four types of EPIYA motifs--ABC (29.4%), ABD (64.7%), ABAB (2%), and AAD (3.9%)--were identified, and the ABD type was found more commonly in severe diseases, such as atrophic gastritis (53.3%) and gastric cancer (71.4%)," wrote J. Li and colleagues, Sun Yat-Sen University, Department of Anatomy. The researchers concluded: "CagA genotypes in children and in adults are different, and EPIYA-ABD may have potential clinical implication in the development of gastric cancer in South China." Li and colleagues published their study in Helicobacter (Distinctiveness of the cagA genotype in children and adults with peptic symptoms in South China. Helicobacter, 2009;14(4):248-55). For additional information, contact J. Li, Zhongshan School of Medicine, Dept. of Anatomy, Sun Yat-sen University, Guangzhou, China. The publisher's contact information for the journal Helicobacter is: Blackwell Publishing Inc., 350 Main St., Malden, MA 02148, USA. Keywords: People's Republic of China, Guangzhou, Helicobacter pylori, Anatomy, Carcinogenesis, DNA Research, DNA Sequence Proteomics, Deoxyribonucleic Acid, Diagnosis, Diagnostics, Enzyme Research, Gastroenterology, Helicobacter, Histology, Infectious Disease, Pediatrics, Polymerase, Urease. This article was prepared by Gastroenterology Week editors from staff and other reports. Copyright 2009, Gastroenterology Week via NewsRx.com.
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