Gastrinoma
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Research from J.A. Goldman and colleagues provide new insights into life sciences
2009 JUN 29 - (NewsRx.com) -- According to a study from the United States, "We report the case of a 22-year-old woman who was referred for evaluation of possible Zollinger-Ellison syndrome because of hypergastrinemia and a positive secretin stimulation rest. She was being treated with proton pump inhibitors (PPIs) for severe gastroesophageal reflux disease during her initial evaluation." "At cessation of PPI therapy, her fasting serum gastrin levels normalized, as did her response to secretin injection. Previous reports describing false-positive secretin tests have been limited to cases of hypergastrinemia in the setting of chronic atrophic gastritis, presumably a result of achlorhydria. This case represents a clearly documented instance of PPI-related hypergastrinemia with a false-positive secretin test, with subsequent normalization of serum gastrin and a negative secretin test after withdrawal of PPI therapy," wrote J.A. Goldman and colleagues. The researchers concluded: "The current case emphasizes the need to assess the acid secretory status of individuals with hypergastrinemia and to discontinue the use of potent antisecretory agents, principally PPIs, to avoid the erroneous diagnosis of gastrinoma and before embarking on expensive and potentially invasive evaluations for the purpose of tumor localization." Goldman and colleagues published their study in Clinical Gastroenterology and Hepatology (False-Positive Secretin Stimulation Test for Gastrinoma Associated With the Use of Proton Pump Inhibitor Therapy. Clinical Gastroenterology and Hepatology, 2009;7(5):600-602). For more information, contact M.M. Wolfe, Boston Med Center, Gastroenterology Sect, 650 Albany St., Room 504, Boston, MA 02118, USA. Publisher contact information for the journal Clinical Gastroenterology and Hepatology is: Elsevier Science Inc., 360 Park Avenue South, New York, NY 10010-1710, USA. Keywords: United States, Boston, Life Sciences, Gastroenterology, Gastroesophageal Reflux Disease, Zollinger-Ellison Syndrome, Acid Reflux, Gastrinomas, Gastritis, Atrophic Gastritis, Treatment, Therapy, Secretin, Pharmaceuticals, Drugs, Clinical Gastroenterology, Hepatology. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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