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Study findings from University of Connecticut broaden understanding of antisense technology
2009 AUG 3 - (NewsRx.com) -- According to a study from the United States, "We show here that expression of genes from convergent transcription units can be regulated by the formation of double-stranded RNA ( dsRNA) in the region of overlapping polyadenylation signals. The model system employed is the mouse polyomavirus." "The early and late genes of polyomavirus are transcribed from opposite strands of the circular viral genome. At early times after infection, the early genes are expressed predominantly. Late gene expression increases dramatically upon the onset of DNA replication, when a major defect in polyadenylation of the late primary transcripts generates multigenomic RNAs that are precursors to the mature late mRNAs. Embedded in these late pre-mRNAs are sequences complementary to the early RNAs that act to down-regulate early gene expression via A-to-I editing of dsRNAs," wrote R. Gu and colleagues, University of Connecticut. The researchers concluded: "In this system, the defective polyadenylation, and consequently the production of multigenomic late RNAs, depends on the context, and perhaps also, on the A-to-I editing of the poly(A) signal that overlaps the 3'-end of early transcripts." Gu and colleagues published the results of their research in RNA - a Publication of the RNA Society (Gene regulation by sense-antisense overlap of polyadenylation signals. RNA - a Publication of the RNA Society, 2009;15(6):1154-1163). For additional information, contact G.G. Carmichael, University of Connecticut, Dept. of Genetics & Development Biology, Stem Cell Institute, Center Health, 263 Farmington Avenue, Farmington, CT 06030, USA. The publisher of the journal RNA - a Publication of the RNA Society can be contacted at: Cold Spring Harbor Laboratory Press, Publications Dept., 500 Sunnyside Blvd., Woodbury, NY 11797-2924, USA. Keywords: United States, Farmington, Antisense Technology, Biotechnology, DNA, DNA Replication, DNA Research, Gene Therapy, Genetics, Genomics, Medical Device, Polyomavirus, Treatment, Virology, University of Connecticut. This article was prepared by Proteomics Weekly editors from staff and other reports. Copyright 2009, Proteomics Weekly via NewsRx.com.
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