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Research results from Emory University update knowledge of epidemiology
2009 JUL 27 - (NewsRx.com) -- New research, 'Sleep-disordered breathing and frailty in the Cardiovascular Health Study Cohort,' is the subject of a report. According to recent research published in the American Journal of Epidemiology, "Sleep-disordered breathing (SDB) is associated with pathophysiology that may influence the development and progression of frailty. Using data collected in 1995-1996, the authors explored the relation between SDB and components of frailty among 1,042 participants of the Cardiovascular Health Study." "Diagnosis of SDB was based on the results of overnight polysomnography, and severe SDB was defined as an apnea-hypopnea index of >30 per hour of sleep. Slow walking speed, low grip strength, exhaustion, low physical activity, and unexplained weight loss were referred to as frailty indicator variables. There were 584 (56%) female and 458 (44%) male participants, and the mean age was 77 (standard deviation, 4) years. There was independent association between severe SDB and 1 or more frailty indicator variables (adjusted odds ratio=4.85, 95% confidence interval: 1.40, 16.78), slow walking speed (adjusted odds ratio=2.67, 95% confidence interval: 1.04, 6.84), and low grip strength (adjusted odds ratio=3.29, 95% confidence interval: 1.36, 7.96) among female study participants," wrote Y.W. Endeshaw and colleagues, Emory University. The researchers concluded: "The finding of an independent association between SDB and frailty indicator variables among older women could have important implications in interventions aimed at preventing or delaying the progression of frailty." Endeshaw and colleagues published their study in American Journal of Epidemiology (Sleep-disordered breathing and frailty in the Cardiovascular Health Study Cohort. American Journal of Epidemiology, 2009;170(2):193-202). For additional information, contact Y.W. Endeshaw, Dept. of Medicine, Division of Geriatrics and Gerontology, Emory University School of Medicine, Atlanta, Georgia 30329 USA.. The publisher's contact information for the American Journal of Epidemiology is: Oxford University Press, Great Clarendon St., Oxford OX2 6DP, England. Keywords: United States, Atlanta, Cardiology, Cardiovascular, Epidemiology, Physiology, Sleep Apnea, Sleep Disorders, Weight Loss. This article was prepared by Cardiovascular Week editors from staff and other reports. Copyright 2009, Cardiovascular Week via NewsRx.com.
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