Glomerulosclerosis
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Studies from L.H. Bao and co-researchers update current data on glomerulosclerosis
2009 JUL 14 - (NewsRx.com) -- "Heritable and acquired diseases of podocytes can result in focal and segmental glomerulosclerosis (FSGS). We modeled FSGS by passively transferring mouse podocyte-specific sheep Abs into BALB/c mice," investigators in the United States report. "BALB/c mice deficient in the key complement regulator, decay-accelerating factor (DAF), but not WT or CD59-deficient BALB/c mice developed histological and ultrastructural features of FSGS, marked albuminuria, periglomerular monocytic and T cell inflammation, and enhanced T cell reactivity to sheep IgG. All of these findings, which are characteristic of FSGS, were substantially reduced by depleting CD4(+) T cells from Daf(-/-) mice. Furthermore, WT kidneys transplanted into Daf(-/-) recipients and kidneys of DAF-sufficient but T cell-deficient Balb/c(nu/nu) mice reconstituted with Daf(-/-) T cells developed FSGS. In contrast, DAF-deficient kidneys in WT hosts and Balb/c(nu/nu) mice reconstituted with DAF-sufficient T cells did not develop FSGS. Thus, we have described what we believe to be a novel mouse model of FSGS attributable to DAF-deficient T cell immune responses," wrote L.H. Bao and colleagues. The researchers concluded: "These findings add to growing evidence that complement-derived signals shape T cell responses, since T cells that recognize sheep Abs bound to podocytes can lead to cellular injury and development of FSGS.." Bao and colleagues published their study in the Journal of Clinical Investigation (Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells. Journal of Clinical Investigation, 2009;119(5):1264-1274). For additional information, contact L.H. Bao, University Chicago, Nephrology Sect, 5841 S Maryland Avenue, MC5100, Chicago, IL 60637, USA. The publisher of the Journal of Clinical Investigation can be contacted at: American Society Clinical Investigation Inc., 35 Research Dr., Ste. 300, Ann Arbor, MI 48103, USA. Keywords: United States, Chicago, Albuminuria, Glomerulosclerosis, Inflammation, Nephrology. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2009, Life Science Weekly via NewsRx.com.
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