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Scientists at Yonsei University, Medical Department publish new data on corneal dystrophies
2009 AUG 17 - (NewsRx.com) -- According to recent research from Seoul, South Korea, "Granular corneal dystrophy type II (GCD II) is an autosomal dominant disorder characterized by age-dependent progressive accumulation of transforming growth factor-beta-induced protein (TGFBIp) deposits in the corneal stroma. Several studies have suggested that corneal fibroblasts may decline with age in response to oxidative stress." "To investigate whether oxidative stress is involved in the pathogenesis of GCD II, we assayed antioxidant enzymes, oxidative damage, and susceptibility to reactive oxygen species-induced cell death in primary cultured corneal fibroblasts (PCFs) from GCD II patients and healthy subjects. We found elevated protein levels of Mn-superoxide dismutase, Cu/Zn-superoxide dismutase, glutathione peroxidase, and glutathione reductase, as well as increased CAT mRNA and decreased catalase protein in GCD II PCFs. Furthermore, catalase is down-regulated in normal PCFs transfected with transforming growth factor-beta-induced gene-h3. We also observed an increase in not only intracellular reactive oxygen species and H2O2 levels, but also malondialdehyde, 4-hydroxynonenal, and protein carbonyls levels in GCD H PCFs. Greater immunoreactivity for malondialdehyde was observed in the corneal tissue of GCD II patients. In addition, we observed a decrease in Bcl-2 and Bcl-xL levels and an increase in Bax and Bok levels in GCD II PCFs. Finally, GCD II PCFs are more susceptible to H2O2-induced cell death," wrote S.I. Choi and colleagues, Yonsei University, Medical Department. The researchers concluded: "Together, these results suggest that oxidative damage induced by decreased catalase is involved in GCD II pathogenesis, and antioxidant agents represent a possible treatment strategy. (Am J Pathol 2009, 175:248-261; DOI: 10.2353/ajpath.2009.081001)." Choi and colleagues published their study in American Journal of Pathology (Decreased Catalase Expression and Increased Susceptibility to Oxidative Stress in Primary Cultured Corneal Fibroblasts from Patients with Granular Corneal Dystrophy Type II. American Journal of Pathology, 2009;175(1):248-261). For additional information, contact E.K. Kim, Yonsei University, College Medical, Dept. of Ophthalmology, 134 Shinchon Dong, Seoul 120752, South Korea. Publisher contact information for the American Journal of Pathology is: American Society Investigative Pathology, Inc., 9650 Rockville Pike, Bethesda, MD 20814-3993, USA. Keywords: South Korea, Seoul, Catalase, Corneal Dystrophies, Corneal Dystrophy, Dietary Supplement, Dismutase, Endocrinology, Enzyme Research, Enzymology, Glutathione, Micronutrient, Ophthalmology, Pathology, Peroxidase, Reductase, Yonsei University, Medical Department. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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