HELLP Syndrome
Return to Library
|
Free HELLP Syndrome Articles |
|
|
|
|
Scientists at Medical University of Vienna target women's health
2009 MAY 11 - (NewsRx.com) -- In this recently published article, scientists in Vienna, Austria conducted a study "To assess the prevalence of delivery complications associated with coagulopathy in women with intrauterine fetal death (IUFD). This is a retrospective cohort study of women with IUFD at > 24 weeks gestation or a birth weight of > 500 g between 1994 and 2007." "Clinical data were assessed by chart review. One hundred four women were diagnosed with IUFD. The mean time between diagnosis of IUFD and delivery was 28.8 (+/- 17.4) hours. Twelve of 104 (11.5%) women had a delivery complication associated with coagulopathy, defined as need for blood transfusion. In 8 of these 12 women, coagulopathy was associated with a preexisting preeclampsia/hemolysis, elevated liver enzymes, low platelet (HELLP) syndrome, uterine rupture after induction, or an acute clinical problem at presentation to the clinic. In 4 of 104 (4%) women, there was no attributable cause of coagulopathy other than IUFD. In these women, there was a statistically significant difference of laboratory parameters of coagulation at the time of diagnosis of IUFD compared with women who did not subsequently develop coagulopathy; platelet count 93.3 +/- 96.4 vs. 229.3 +/- 68.1 G/L, p< 0.001; prothrombin time (PT) 97.0 +/- 43.9 vs. 123.3 +/- 21.1 %, p = 0.02; activated partial thromboplastin time (aPTT) 42.9 +/- 34.0 vs. 31.5 +/- 4.3 sec, p = 0.01; thrombin time (TT) 22.8 +/- 16.5 vs. 14.1 +/- 13.3 sec, p = 0.02), plasma fibrinogen 219.0 +/- 117.5 vs. 472.9 +/- 122.8 mg/dL, p< 0.001), and antithrombin III 70.5 +/- 21.9 vs. 101.5 +/- 17.0 %, p = 0.01. Delivery complications associated with coagulopathy occur in 11% of women with IUFD and are associated with preexisting preeclampsia/HELLP, uterine rupture, or an acute clinical problem in most cases," wrote C.B. Tempfer and colleagues, Medical University of Vienna. The researchers concluded: "In 4% of women with IUFD, coagulopathy develops without an apparent cause." Tempfer and colleagues published their study in the Journal of Womens Health (Intrauterine Fetal Death and Delivery Complications Associated with Coagulopathy: A Retrospective Analysis of 104 Cases. Journal of Womens Health, 2009;18(4):469-474). For additional information, contact C.B. Tempfer, Medical University of Vienna, Dept. of Obstetrics & Gynecology, Waehringer Guertel 18-20, A-1090 Vienna, Austria. The publisher's contact information for the Journal of Womens Health is: Mary Ann Liebert Inc., 140 Huguenot Street, 3RD FL, New Rochelle, NY 10801, USA. Keywords: Austria, Vienna, Women's Health, Birth Weight, Blood Transfusion, Clinical Trial Research, Coagulation, Eclampsia, Gynecology, HELLP Syndrome, Hemolysis, Medical Device, Obstetrics, Preeclampsia, Transfusion Medicine, Uterine Health, Uterine Rupture, Medical University of Vienna. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
|
