Hamartoma
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Scientists at Shanghai University detail research in cholangio cancer
2009 JUN 22 - (NewsRx.com) -- "Multiple bile duct hamartomas (BDHs)/von Meyenburg complexes, are tumor-like lesions of the liver. Malignant transformation in BDHs has been previously reported in very rare instances, and the most common tumor arising in this clinical setting is cholangiocarcinoma," scientists in Shanghai, People's Republic of China report. "Herein, we report on clinicopathological findings in two cases of cholangiocarcinoma occurring in liver with multiple BDHs. Histopathologically, multiple BDHs showed morphologic transition from clearly benign to dysplasia or carcinoma in situ, then to invasive carcinoma sequence of the biliary epithelium. The neoplastic epithelium showed positivity for cytokeratin 19, CA 19-9, and epithelial membrane antigen. Staining for Hep Par 1, alpha-fetoprotein, cytokeratin 20, and alpha 1-antitrypsin was negative. All sections from the nonneoplastic liver in each specimen showed multiple BDHs. Any other clinically detectable primary tumor was not found. These two neoplasms were interpreted as a cholangiocarcinoma arising in BDHs," wrote A.M. Xu and colleagues, Shanghai University. The researchers concluded: "This suggested BDHs might be a risk factor of development of cholangiocarcinoma." Xu and colleagues published their study in European Journal of Gastroenterology & Hepatology (Intrahepatic cholangiocarcinoma arising in multiple bile duct hamartomas: report of two cases and review of the literature. European Journal of Gastroenterology & Hepatology, 2009;21(5):580-584). For more information, contact S.H. Zhang, Shanghai University Tradit Chinese Medical, Yueyang Hospital, Dept. of Pathology, 110 Ganhe Rd., Shanghai, People's Republic of China. Publisher contact information for the European Journal of Gastroenterology & Hepatology is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA. Keywords: People's Republic of China, Shanghai, Carcinoma in Situ, Cholangio Cancer, Cholangio Carcinoma, Dermatology, Dysplasia, Gastroenterology, Hamartoma, Hepatology, Invasive Carcinoma, Oncology, Shanghai University. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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