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New research on hypertrophic cardiomyopathy cell biology from Nagoya University, Department of Cardiology summarized
2009 AUG 17 - (NewsRx.com) -- Investigators publish new data in the report 'Relation of functional and morphological changes in mitochondria to myocardial contractile and relaxation reserves in asymptomatic to mildly symptomatic patients with hypertrophic cardiomyopathy.' In this recent report published in the European Heart Journal, researchers in Nagoya, Japan conducted a study "To examine the relation between mitochondrial dysfunction and myocardial contractile and relaxation reserves in hypertrophic cardiomyopathy (HCM). Thirty HCM patients (LVEF >or=60%) underwent biventricular cardiac catheterization analysis both at rest and during atrial pacing as well as myocardial (99m)Tc-sestamibi scintigraphy at rest to calculate washout rate." "Endomyocardial biopsy specimens were obtained for quantitative mRNA analysis and electron microscopy. The HCM patients were divided into two groups-group A: normal force-frequency relation and a pressure half-time (T(1/2)) of <30 ms (n=15); group B: abnormal force-frequency relation or T(1/2) of >or=30 ms (n=15). The (99m)Tc-sestamibi washout rate was significantly correlated with T(1/2) for all patients (r=0.74, p<0.01) and was also significantly greater in group B (29.2 ±6.3%) than in group A (19.3 ±3.1%). The abundance of mRNAs for mitochondrial electron transport-related enzymes was significantly higher in group A than in group B. Mitochondria showed a greater variation in size and were more disorganized in group B than in group A. Mitochondria showed functional impairment and morphological disorganization in the left ventricle of HCM patients without baseline systolic dysfunction," wrote K. Unno and colleagues, Nagoya University, Department of Cardiology. The researchers concluded: "These mitochondrial changes were associated with impaired myocardial contractile and relaxation reserves." Unno and colleagues published their study in European Heart Journal (Relation of functional and morphological changes in mitochondria to myocardial contractile and relaxation reserves in asymptomatic to mildly symptomatic patients with hypertrophic cardiomyopathy. European Heart Journal, 2009;30(15):1853-62). For additional information, contact K. Unno, Nagoya University Graduate School of Medicine, Dept. of Cardiology, Nagoya, Aichi 466-8550, Japan. The publisher's contact information for the European Heart Journal is: Oxford University Press, Great Clarendon St., Oxford OX2 6DP, England. Keywords: Japan, Nagoya, Hypertrophic Cardiomyopathy Cell Biology, Biopsy, Cardiology, Cardiomyopathies, Cell Biology, Electron Microscopy, Heart Catheterization, Hypertrophic Cardiomyopathy, Surgery. This article was prepared by Cardiovascular Week editors from staff and other reports. Copyright 2009, Cardiovascular Week via NewsRx.com.
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