Hemolysis
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Studies from A. Ozer et al add new findings in the area of HELLP syndrome
2009 JUL 13 - (NewsRx.com) -- "The present study aims to investigate the effects of betamethasone treatment on clinical outcome and laboratory data of pregnant women diagnosed with HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome. A prospective, randomized and placebo-controlled clinical trial was undertaken in a total of 60 pregnant women with HELLP syndrome who were treated at the perinatology department of the study center between January 2005 and February 2008," scientists writing in the journal Archives of Gynecology and Obstetrics report. "Betamethasone treatment (intramuscular injection of 12 mg in every 24 h) was given to 30 subjects while remaining 30 subjects received placebo. The treatment and control groups were compared in the aspects of clinical outcome and laboratory data. The alterations in platelet counts, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase levels of women treated with betamethasone were statistically similar to those of the placebo group. Although there was a significant decrease in diastolic blood pressure values of control group (P = 0.04), alterations in systolic blood pressure values were statistically indifferent in both study groups. Hematological and metabolic complications occurred significantly less in women treated with betamethasone (P < 0.05). Interestingly, the percentage of women who received platelet transfusion was significantly higher in the control group (P < 0.005). No case of maternal mortality occurred. The betamethasone treatment has ended up with insignificant alterations in clinical outcomes and laboratory data of women with HELLP syndrome except beneficial effects on metabolic complications and need for platelet transfusion," wrote A. Ozer and colleagues. The researchers concluded: "Further investigation is required to assess the efficiency of betamethasone in management of HELLP syndrome.." Ozer and colleagues published their study in Archives of Gynecology and Obstetrics (The effects of betamethasone treatment on clinical and laboratory features of pregnant women with HELLP syndrome. Archives of Gynecology and Obstetrics, 2009;280(1):65-70). Additional information can be obtained by contacting A. Ozer, Ertugrul Gazi Mah Kutlugun Sok, 37-14 Iccebeci, TR-06590 Ankara, Turkey. The publisher of the journal Archives of Gynecology and Obstetrics can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. Keywords: Turkey, Ankara, Betamethasone, Clinical Trial Research, Corticosteroid, Drugs, Eclampsia, Gynecology, HELLP Syndrome, Hemolysis, Maternal Mortality, Obstetrics, Perinatology, Pharmaceuticals, Preeclampsia, Therapy, Treatment, Women's Health. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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