Hemorrhagic Shock
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Study findings from P. Cabrates et al provide new insights into hemorrhagic shock
2007 DEC 24 -- According to a study from the United States, "Systemic and microvascular hemodynamic responses to transfusion of oxygen using functional and non-functional packed fresh red blood cells (RBCs) from hemorrhagic shock were studied in the hamster window chamber model to determine the significance of RBCs on rheological and oxygen transport properties. Moderate hemorrhagic shock was induced by arterial controlled bleeding of 50% of the blood volume, and a hypovolemic state was maintained for 1 h. Volume restitution was performed by infusion of the equivalent of 2.5 units of packed cells, and the animals were followed for 90 min." "Resuscitation study groups were non-oxygen functional fresh RBCs where the hemoglobin (Hb) was converted to methemoglobin (MetHb) [MetRBC], fully oxygen functional fresh RBCs [OxyRBC] and 10% hydroxyethyl starch [HES] as a volume control solution. Measurement of systemic variables, microvascular hemodynamics and capillary perfusion were performed during the hemorrhage, hypovolemic shock and resuscitation. Final blood viscosities after the entire protocol were 3.8 cP for transfusion of RBCs and 2.9 cP for resuscitation with HES (baseline: 4.2 cP). Volume restitution with RBCs with or without oxygen carrying capacity recovered higher mean arterial pressure (MAP) than HES. Functional capillary density (FCD) was substantially higher for transfusion versus HES, and the presence of MetHb in the fresh RBC did not change FCD or microvascular hemodynamics. Oxygen delivery and extraction were significantly tower for resuscitation with HES and MetRBC compared to OxyRBC," wrote P. Cabrates and colleagues. The researchers concluded: "Incomplete re-establishment of perfusion after resuscitation with HES could also be a consequence of the inappropriate restoration of blood rheological properties which unbalance compensatory mechanisms, and appear to be independent of the reduction in oxygen carrying capacity." Cabrates and colleagues published their study in Resuscitation (Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity. Resuscitation, 2007;75(1):124-134). For more information, contact P. Cabrates, La Jolla Bioengineering Institute, 505 Coast Blvd. S Suite 405, La Jolla, CA 92037, USA. Publisher contact information for the journal Resuscitation is: Elsevier Ireland Ltd., Elsevier House, Brookvale Plaza, East Park Shannon, Co. Clare, Ireland. Keywords: United States, La Jolla, Angiology, Blood Transfusion, Circulation, Hemorrhage, Hemorrhagic Shock, Intravascular, Medical Device, Microcirculation, Perfusion, Transfusion Medicine. This article was prepared by Hematology Week editors from staff and other reports. Copyright 2007, Hematology Week via NewsRx.com.
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