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Recent Findings in Peptide Hormones Described by Researchers from Johns Hopkins University

2013 JAN 22 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Peptide Proteins. According to news reporting from Baltimore, Maryland, by NewsRx journalists, research stated, "The goal of this study was to explore the feasibility of targeted imaging of the angiotensin II type 1 receptor (AT1R) in cardiac tissue, using clinical hybrid positron emission tomography/computed tomography (PET/CT). AT1R is an attractive imaging target due to its key role in various cardiac pathologies, including post-infarct left ventricular remodeling."

The news correspondents obtained a quote from the research from Johns Hopkins University, "Using the novel AT1R ligand [C-11]-KR31173, dynamic PET/CT was performed in young farm pigs under healthy conditions (n = 4) and 3 to 4 weeks after experimental myocardial infarction (n = 5). Ex vivo validation was carried out by immunohistochemistry and polymerase chain reaction. First-in-man application was performed in 4 healthy volunteers at baseline and under AT1R blocking. In healthy pigs, myocardial KR31173 retention was detectable, regionally homogeneous, and specific for AT1R, as confirmed by blocking experiments. Metabolism in plasma was low (85 +/- 2% of intact tracer after 60 min). After myocardial infarction, KR31173 retention, corrected for regional perfusion, revealed AT1R up-regulation in the infarct area relative to remote myocardium, whereas retention was elevated in both regions when compared with myocardium of healthy controls (8.7 +/- 0.8% and 7.1 +/- 0.3%/min vs. 5.8 +/- 0.4%/min for infarct and remote, respectively, vs. healthy controls; p< 0.01 each). Postmortem analysis confirmed AT1R up-regulation in remote and infarct tissue. First-in-man application was safe, and showed detectable and specific myocardial KR31173 retention, albeit at a lower level than pigs (left ventricular average retention: 1.2 +/- 0.1%/min vs. 4.4 +/- 1.2%/min for humans vs. pigs; p = 0.04). Noninvasive imaging of cardiac AT1R expression is feasible using clinical PET/CT technology."

According to the news reporters, the research concluded: "Results provide a rationale for broader clinical testing of AT1R-targeted molecular imaging."

For more information on this research see: Molecular Hybrid Positron Emission Tomography/Computed Tomography Imaging of Cardiac Angiotensin II Type 1 Receptors. Journal of the American College of Cardiology, 2012;60(24):2527-2534. Journal of the American College of Cardiology can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA.

Our news journalists report that additional information may be obtained by contacting K. Fukushima, Johns Hopkins University, Div Cardiol, Dept. of Med, Baltimore, MD, United States.

Keywords for this news article include: Maryland, Baltimore, Autacoids, United States, Neuropeptides, Oligopeptides, Angiotensin II, Peptide Hormones, Peptide Proteins, Imaging Technology, Computed Tomography, Nerve Tissue Proteins, North and Central America

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