Research from University of Bergen in the area of influenza published
2007 NOV 20 -- "The threat of a new influenza pandemic has led to renewed interest in dose-sparing vaccination strategies such as intradermal immunization and the use of adjuvanted vaccines. In this study we compared the quality and kinetics of the serum antibody response elicited in mice after one or two immunizations with a split influenza A (H3N2) virus, using three different low-dose vaccination strategies," scientists in Bergen, Norway report. "The mice were divided into four groups, receiving either a low-dose vaccine (3 mu g hemagglutinin [HA]) intradermally or intramuscularly with or without aluminum adjuvant or the normal human vaccine dose (15 jig HA) intramuscularly. Sera were collected weekly after vaccination and tested in the hemagglutination inhibition, virus neutralization, and enzyme-linked immunosorbent assays. The antibody responses induced after intradermal or intramuscular low-dose vaccinations were similar and lower than those observed after the human vaccine dose. However, low-dose adjuvanted vaccine elicited a serum antibody response comparable to that elicited by the human dose, although the second immunization did not result in any increase in cross-reactive hemagglutination inhibition antibodies, and the peak serum antibody response was observed 1 week later than in the other vaccination groups. Our murine data suggest that the low-dose intradermal route does not show any obvious advantage over the low-dose intramuscular route in inducing a serum antibody response and that none of the low-dose vaccination strategies is as effective as intramuscular vaccination with the normal human dose," wrote S. Hauge and colleagues, University of Bergen. The researchers concluded: "However, the low-dose aluminum-adjuvanted vaccine could present a feasible alternative in case of limited vaccine supply." Hauge and colleagues published their study in Clinical and Vaccine Immunology (Quality and kinetics of the antibody response in mice after three different low-dose influenza virus vaccination strategies. Clinical and Vaccine Immunology, 2007;14(8):978-983). For more information, contact S. Hauge, University of Bergen, Influenza Center, Grade Institute, Armauer Hansen Bldg, N-5021 Bergen, Norway. Publisher contact information for the journal Clinical and Vaccine Immunology is: American Society Microbiology, 1752 N St. NW, Washington, DC 20036-2904, USA. Keywords: Norway, Bergen, Flu, Influenza, University of Bergen. This article was prepared by Virus Weekly editors from staff and other reports. Copyright 2007, Virus Weekly via NewsRx.com.
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