Recent findings from H. Le Buanec and co-authors highlight research in allergic reactions vaccines
2007 NOV 20 -- Current study results from the report, 'Control of allergic reactions in mice by an active anti-murine IL-4 immunization,' have been published. "Pathogenesis of allergic inflammatory disorders is characterized by allergen-induced IgE stimulated by Th2 cytokines including mainly IL-4 overproduction. To counteract IL-4 effects in sensitized-BALB/c mice, we prepared an IL-4 derivative immunogen, made of KLH and murine IL-4 heterocomplex, termed mIL-4 kinoid," scientists writing in the journal Vaccine report. "Murine IL-4 kinoid immunized mice produced high titer of anti-IL-4 neutralizing Abs. In contrast to KLH control immunization kinoid immunization reversed the allergic IgE:IgG ratio hallmark in rBet v 1a sensitized mice and reduced pulmonary eosinophil recruitment and bronchial hyperreactivity in Ova-sensitized mice," wrote Buanec H. Le and colleagues, . The researchers concluded: "These data pave the way to alternative therapies to combat allergic conditions." Le and colleagues published their study in Vaccine (Control of allergic reactions in mice by an active anti-murine IL-4 immunization. Vaccine, 2007;25(41):7206-16). Additional information can be obtained by contacting H. Le Buanec, Neovacs, SA 3-5 Impasse Reille, F-75014 Paris, France. The publisher of the journal Vaccine can be contacted at: Elsevier Science Ltd., the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. Keywords: France, Paris, Allergic Reactions Vaccines, Allergic Reactions, Biotechnology, Vaccines. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
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