Immunology

Study findings from X.N. Dong et al provide new insights into vaccine

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"Many epitopes lie on the surface of alpha-helix. These epitopes are not easy to be recruited into the vaccine development, because they are conformation dependent epitopes," wrote X.N. Dong and colleagues.

The researchers concluded: "Can such epitopes on alpha-helix be mimicked synthetically? Our findings undoubtedly validate the feasibility of surface simulation synthesis with short linear peptide to mimic the antigenic side of alpha-helix structure."

Dong and colleagues published their study in Vaccine (Surface simulation synthesis: A new strategy to spy alpha-helix structure. Vaccine, 2007;25(36):6569-6571).

For additional information, contact X.N. Dong, Tsing Hua University, Dept. of Biology, Minist Education, Prot Science Laboratory, Laboratory Immunology, Beijing 100084, People's Republic of China.

Publisher contact information for the journal Vaccine is: Elsevier Science Ltd., the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England.

Keywords: People's Republic of China, Beijing, Life Sciences, Acquired Immunodeficiency Syndrome, Human Immunodeficiency Virus, AIDS, HIV, Virology, Vaccine.

This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2007, Vaccine Weekly via NewsRx.com.