Research from University of Virginia in the area of immunology described
2007 NOV 21 -- According to a study from the United States, "Antigens recognized by T cells are expressed as peptides bound to major histocompatibility complex (MHC) molecules. Microcapillary high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry was used to fractionate and sequence subpicomolar amounts of peptides isolated from the MHC molecule HLA-A2.1." "Of 200 different species quantitated, eight were sequenced and four were found in cellular proteins. All were nine residues long and shared a distinct structural motif," wrote D.F. Hunt and colleagues, University of Virginia. The researchers concluded: "The sensitivity and speed of this approach should enhance the analysis of peptidcs from small quantities of vitally infected and transformed cells as well as those associated with autoinumme disease states." Hunt and colleagues published the results of their research in the Journal of Immunology (Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry (Reprinted from Science, vol 255, March 6, 1992). Journal of Immunology, 2007;179(5):2669-2671). For additional information, contact D.F. Hunt, University of Virginia, Dept. of Chemical, Mccormick Rd., Charlottesville, VA 22903, USA. The publisher of the Journal of Immunology can be contacted at: American Association Immunologists, 9650 Rockville Pike, Bethesda, MD 20814, USA. Keywords: United States, Charlottesville, Immunology, University of Virginia. This article was prepared by Immunotherapy Weekly editors from staff and other reports. Copyright 2007, Immunotherapy Weekly via NewsRx.com.
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